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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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18 recruiting trials

for Diffuse Midline Glioma, H3 K27M-Mutant

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors NCT06624371Phase 12 sites📍 Atlanta📍 Atlanta Emory University · Tests: Atovaquone, Radiation Therapy CAR T Cells to Target GD2 for DMG NCT05544526Phase 11 site📍 London University College, London · Tests: GD2 CAR T cells Combination Therapy for the Treatment of Diffuse Midline Gliomas NCT05009992Phase 232 sites📍 Birmingham📍 Los Angeles📍 San Diego University of California, San Francisco · Tests: ONC201, Radiation Therapy, Paxalisib, DNX-2401 ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors NCT04732065Phase 17 sites📍 San Francisco📍 Washington D.C.📍 Atlanta Sabine Mueller, MD, PhD · Tests: ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification NCT05259605n/a42 sites📍 Innsbruck📍 Vienna📍 Aalst European Organisation for Research and Treatment of Cancer … · Tests: Observational CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site📍 Minneapolis OX2 Therapeutics · Tests: Treatment with CD200AR-L ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) NCT05580562Phase 3162 sites📍 Phoenix📍 Phoenix📍 Phoenix Jazz Pharmaceuticals · Tests: Dordaviprone (ONC201), Dordaviprone (ONC201) + Placebo, Placebo Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 NCT05476939Phase 356 sites📍 Brussels📍 Leuven📍 Aarhus Gustave Roussy, Cancer Campus, Grand Paris · Tests: Everolimus, ONC201, Radiotherapy Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant NCT05843253Phase 220 sites📍 Aurora📍 Washington D.C.📍 Chicago Nationwide Children's Hospital · Tests: Ribociclib, Everolimus, Temozolomide (TMZ) A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma NCT07589257Phase 21 site📍 Guangzhou Guangzhou Virotech Pharmaceutical Co., Ltd. · Tests: VRT106 for injection Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation NCT07076498Phase 11 site📍 Houston M.D. Anderson Cancer Center · Tests: M032 rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG NCT04943848Phase 13 sites📍 Orange📍 Chicago📍 Boston Ann & Robert H Lurie Children's Hospital of Chicago · Tests: rHSC-DIPGVax, Balstilimab, Zalifrelimab A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors NCT06357377Phase 11 site📍 Orange Neonc Technologies, Inc. · Tests: NEO100 FUS Etoposide for DMG NCT05762419Phase 11 site📍 New York Columbia University · Tests: Etoposide; Oral, 50 Mg, Focused ultrasound with neuro-navigator-controlled sonication Targeted Pediatric High-Grade Glioma Therapy NCT05839379n/a22 sites📍 Aurora📍 Washington D.C.📍 Miami Nationwide Children's Hospital Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms NCT04541082Phase 11 site📍 Bethesda Jazz Pharmaceuticals · Tests: ONC206 International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository NCT03101813n/a1 site📍 Cincinnati Children's Hospital Medical Center, Cincinnati Study of Olutasidenib and Temozolomide in HGG NCT06161974Phase 220 sites📍 Aurora📍 Washington D.C.📍 Miami Rigel Pharmaceuticals · Tests: Olutasidenib + TMZ
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