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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Grade 1 Glioma

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma NCT04166409Phase 3132 sites๐Ÿ“ Birmingham๐Ÿ“ Mesa๐Ÿ“ Phoenix National Cancer Institute (NCI) ยท Tests: Biospecimen Collection, Carboplatin, Echocardiography Test, Magnetic Resonance Imaging, Questionnaire Administration Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Intracranial Genetically Modified Immune Cells (TGFฮฒR2KO/IL13Rฮฑ2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial โ€ฆ A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases NCT07268053EARLY Phase 11 site๐Ÿ“ Phoenix Nader Sanai ยท Tests: Risvutatug rezetecan ABY-029 Glioma Trial NCT07063693Phase 11 site๐Ÿ“ Lebanon Dartmouth-Hitchcock Medical Center ยท Tests: ABY-029 ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors NCT04732065Phase 17 sites๐Ÿ“ San Francisco๐Ÿ“ Washington D.C.๐Ÿ“ Atlanta Sabine Mueller, MD, PhD ยท Tests: ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells NCT04254419Phase 11 site๐Ÿ“ Columbus Nationwide Children's Hospital ยท Tests: NK cells Study of Letrozole in Recurrent Gliomas NCT03122197EARLY Phase 11 site๐Ÿ“ Cincinnati University of Cincinnati ยท Tests: Letrozole Oral Tablet, Temozolomide Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy NCT05180825Phase 225 sites๐Ÿ“ Amiens๐Ÿ“ Angers๐Ÿ“ Besanรงon University Hospital, Strasbourg, France ยท Tests: Trametinib, Vinblastine Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07551336Phase 11 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: Dual-target CAR-NK cells, Cyclophosphamide, Intracranial catheter/reservoir for locoregional delivery, Fludarabine Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma NCT06410248Phase 11 site๐Ÿ“ Chicago Northwestern University ยท Tests: Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration, Resection, Temozolomide 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours NCT06630260Phase 1, Phase 23 sites๐Ÿ“ Cambridge๐Ÿ“ Sutton๐Ÿ“ Sutton Institute of Cancer Research, United Kingdom ยท Tests: Avutometinib, Defactinib, Temozolomide TMZ + RT + 5-ALA + LIDU SDT System for Newly Diagnosed Butterfly Glioma NCT07862647Phase 11 site๐Ÿ“ Buffalo Alpheus Medical, Inc. ยท Tests: 5-ALA, Porphyrin Metabolite Activation (PoMA) with LIDU ultrasound Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma NCT04590664Phase 1, Phase 21 site๐Ÿ“ Atlanta Emory University ยท Tests: Verteporfin A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. NCT07017816EARLY Phase 11 site๐Ÿ“ Washington D.C. Children's National Research Institute ยท Tests: SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma NCT07061626Phase 11 site๐Ÿ“ Chicago Cerenome ยท Tests: Rhenium-186 Nanoliposome SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma NCT04923126Phase 1, Phase 21 site๐Ÿ“ Memphis St. Jude Children's Research Hospital ยท Tests: Mirdametinib First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor NCT07755397Phase 16 sites๐Ÿ“ Surat๐Ÿ“ Bangalore๐Ÿ“ Mumbai Jubilant Therapeutics India Limited ยท Tests: JBI-778 A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy NCT05789394Phase 11 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Allogeneic Adipose-derived Mesenchymal Stem Cells, Biospecimen Collection, Craniotomy, Magnetic Resonance Imaging, Ommaโ€ฆ Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites๐Ÿ“ New York๐Ÿ“ Durham Duke University ยท Tests: MVR-C5252 Sitagliptin in Recurrent/Progressive Grade 4 Glioma NCT07541781Phase 11 site๐Ÿ“ Iowa City Kailin Yang, MD, PhD ยท Tests: Sitagliptin, Bevacizumab A Study of 177Lu-PSMA-617 in People With Gliomas NCT07223034Phase 17 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Temozolomide, 177Lu-PSMA-617, 68Ga-PSMA-PET scan/ MRI, Quality of Life Questionnaires A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations NCT05503797Phase 270 sites๐Ÿ“ Beverly Hills๐Ÿ“ San Francisco๐Ÿ“ Westwood, Los Angeles Fore Biotherapeutics ยท Tests: Plixorafenib Preoperative Proton Irradiation for High-grade Brain Gliomas. NCT07710040Phase 11 site๐Ÿ“ Obninsk National Medical Research Radiological Centre of the Ministโ€ฆ ยท Tests: Preoperative irradiation Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease NCT07703436Phase 212 sites๐Ÿ“ Los Angeles๐Ÿ“ San Francisco๐Ÿ“ New Haven Nuvation Bio Inc. ยท Tests: Safusidenib Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK NCT06666348Phase 1, Phase 210 sites๐Ÿ“ Calgary๐Ÿ“ Edmonton๐Ÿ“ Vancouver St. Justine's Hospital ยท Tests: Mirdametinib SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) NCT05303519Phase 361 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Phoenix Nuvation Bio Inc. ยท Tests: safusidenib, Placebo
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