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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for IDH1 Mutation

Olutasidenib Combined With Co-targeted Therapy in Relapsed or Refractory IDH1-mutated Myeloid Malignancies Harboring Activated Signaling Pathway Mutations NCT07032727Phase 22 sites📍 Miami📍 Houston M.D. Anderson Cancer Center · Tests: Olutasidenib, Cladribine (CLAD), Venetoclax, Gilteritinib, Ruxolitinib A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia. NCT06566742Phase 22 sites📍 Miami📍 Houston M.D. Anderson Cancer Center · Tests: Olutasidenib A Phase II Open-label Study of Olutasidenib Post-transplant Maintenance Therapy for Patients With IDH1-mutated Myeloid Malignancies NCT06668584Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Olutasidenib Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant NCT06543381Phase 12 sites📍 Duarte📍 Cleveland City of Hope Medical Center · Tests: Biospecimen Collection, Olutasidenib Olutasidenib in Relapsed IDH1 Mutated AML Patients Who Have Previously Received Venetoclax NCT07471841Phase 21 site📍 Winston-Salem Timothy Pardee · Tests: Olutasidenib, Azacitidine (AZA) a New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia NCT07007949Phase 21 site📍 Suzhou The First Affiliated Hospital of Soochow University · Tests: Ivosidenib combined with venetoclax and azacitidine, Ivosidenib combined with venetoclax and azacitidine An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m Acute Myeloid Leukemia (AML) Ineligible for Intensive Induction Chemotherapy. NCT05907057Phase 315 sites📍 Vienna📍 Wels📍 Marseille Servier Affaires Médicales · Tests: Ivosidenib 500mg Oral Tablet, Azacitidine Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712Phase 11 site📍 New York Jeffrey N. Bruce · Tests: Topotecan An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy. NCT07282262Phase 21 site📍 Beijing Peking Union Medical College Hospital · Tests: Ivosidenib, Lenvatinib, PD-1/PD-L1 inhibitor Olutasidenib With Azacitidine Followed by Olutasidenib Maintenance for the Treatment of IDH1-mutated Acute Myeloid Leukemia in Patients With Prior Treatment With Venetoclax Plus a Hypomethylating Agent NCT07304011Phase 22 sites📍 Orange📍 Sacramento University of California, Davis · Tests: Azacitidine, Olutasidenib A Study of an IDH1m Inhibitor in Participants With IDH1-Mutated Malignancies and Hepatic or Renal Impairment NCT07006688Phase 120 sites📍 Atlanta📍 Columbus📍 Houston Servier Bio-Innovation LLC · Tests: Ivosidenib Oral Tablet Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis: NCT07608003n/a1 site📍 Changsha Xiangya Hospital of Central South University Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies NCT03471260Phase 1, Phase 24 sites📍 Boston📍 Cleveland📍 Portland M.D. Anderson Cancer Center · Tests: Azacitidine, Ivosidenib, Venetoclax Diagnostic and Therapeutic Targets in Cartilaginous Tumours NCT07315542n/a1 site📍 Brno St. Anne's University Hospital Brno, Czech Republic · Tests: Tumour tissue analysis, Molecular validation, Liquid biopsy analysis 000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations NCT05588141Phase 1, Phase 21 site📍 Bethesda National Cancer Institute (NCI) · Tests: Zotiraciclib Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy NCT07075016Phase 3119 sites📍 Feldkirch📍 Salzburg📍 Vienna Stichting Hemato-Oncologie voor Volwassenen Nederland · Tests: Venetoclax 400, Placebo Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation NCT07286292Phase 25 sites📍 Los Angeles📍 Chicago📍 Boston Institut de Recherches Internationales Servier (I.R.I.S.) · Tests: Vorasidenib A Clinical Trial of Olutasidenib in Patients With Acute Myeloid Leukemia NCT07604064Phase 21 site📍 Tokyo and Other Japanese Cities Kissei Pharmaceutical Co., Ltd. · Tests: Olutasidenib Phase I Study of HMPL-306 for the Treatment of Gliomas With IDH1 and/or IDH2 Mutations NCT07025018Phase 11 site📍 Shanghai Hutchmed · Tests: HMPL-306 A Study to Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia NCT06387069Phase 353 sites📍 Hefei📍 Hefei📍 Hefei Hutchmed · Tests: HMPL-306 Regimen, Salvage Chemotherapy Regimen Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation NCT02074839Phase 130 sites📍 Birmingham📍 Phoenix📍 Duarte Institut de Recherches Internationales Servier · Tests: AG-120 Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation NCT06291987Phase 12 sites📍 Chicago📍 Milwaukee University of Chicago · Tests: Ivosidenib, Ruxolitinib Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation NCT06717958Phase 217 sites📍 Aachen📍 Chemnitz📍 Dresden Technische Universität Dresden · Tests: Ivosidenib 250 MG (milligram) Ivosidenib as Post-HSCT Maintenance for AML NCT06707493Phase 27 sites📍 Atlanta📍 Kansas City📍 Boston Massachusetts General Hospital · Tests: Ivosidenib, Placebo Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen NCT06127407Phase 3115 sites📍 Los Angeles📍 Santa Monica📍 Aurora Servier Bio-Innovation LLC · Tests: Ivosidenib 500mg, Placebo Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies NCT07486713Phase 42 sites📍 Orange📍 New York Rigel Pharmaceuticals · Tests: Olutasidenib, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and OATP1B1 Probe Substrates Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML NCT06611839Phase 1, Phase 21 site📍 Tianjin Institute of Hematology & Blood Diseases Hospital, China · Tests: Ivosidenib, Venetoclax, Azacitidine Ivosidenib as Maintenance Therapy in Transplant-Ineligible IDH1-mutated AML and HR-MDS NCT07607418Phase 21 site📍 Shanghai Ruijin Hospital · Tests: Ivosidenib ctDNA in Genetic Profiling and Clinical Outcomes of Advanced Biliary Tract Cancer NCT07151118n/a1 site📍 Seongnam-si CHA University · Tests: Blood Sampling for ctDNA Analysis Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation NCT06465953Phase 362 sites📍 Denver📍 Chicago📍 Boston Institut de Recherches Internationales Servier · Tests: Ivosidenib, Azacitidine
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