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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

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7 recruiting trials

for Leptomeningeal Metastasis From Lung Cancer

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer NCT06304441NA1 site📍 Huizhou Guangzhou Medical University · Tests: Osimertinib, Pemetrexed Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer NCT07559097Phase 1, Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: Methotrexate-loaded vesicles Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer NCT06518057Phase 23 sites📍 San Francisco📍 New York📍 Seattle University of Washington · Tests: Biospecimen Collection, Computed Tomography, Electronic Health Record Review, Lumbar Puncture, Magnetic Resonance Imagi… Amivantamab Combined With Intrathecal Pemetrexed for LM From EGFR-Mutated Lung Adenocarcinoma NCT07744529Phase 1, Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Amivantamab+ systemic/ intrathecal Pemetrexed Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. NCT06296745Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: Pemetrexed ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase NCT07751536NA3 sites📍 Hefei📍 Hefei📍 Nanjing Shuanghu Yuan · Tests: proton craniospinal irradiation, Intrathecal pemetrexed BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies NCT07789912NA1 site📍 Miami University of Miami · Tests: Radiation Treatments Using Brain- Avoidant Proton Craniospinal Irradiation (BRAVO- pCSI)
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