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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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16 recruiting trials

for Locally Advanced Bladder Urothelial Carcinoma

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3 NCT05614739Phase 182 sites๐Ÿ“ Tucson๐Ÿ“ Duarte๐Ÿ“ Los Angeles Eli Lilly and Company ยท Tests: Vepugratinib, Pembrolizumab, enfortumab vedotin, Trastuzumab Deruxtecan, Midazolam Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial NCT06764095Phase 41 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Biospecimen Collection, Computed Tomography, Cystectomy, Enfortumab Vedotin, Local Therapy Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma NCT07129993Phase 2, Phase 3100 sites๐Ÿ“ Fullerton๐Ÿ“ Glendale๐Ÿ“ La Jolla Daiichi Sankyo ยท Tests: Dato-DXd, Carboplatin, Cisplatin, Gemcitabine EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC NCT07647289Phase 21 site๐Ÿ“ Beijing Peking University Third Hospital ยท Tests: enfortumab vedotin (EV), Toripalimab, Gemcitabine (Chemotherapy), Cisplatin A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors NCT07020117Phase 114 sites๐Ÿ“ Duarte๐Ÿ“ Irvine๐Ÿ“ Miami Aktis Oncology, Inc. ยท Tests: [225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging) A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031) NCT07419295Phase 3107 sites๐Ÿ“ Washington D.C.๐Ÿ“ Atlanta๐Ÿ“ Baltimore Merck Sharp & Dohme LLC ยท Tests: Sacituzumab tirumotecan, Vinflunine, Docetaxel, Paclitaxel, Rescue medications for sacituzumab tirumotecan Enfortumab Vedotin, Pembrolizumab and Quemliclustat for the Treatment of Unresectable Locally Advanced and Metastatic Urothelial Cancer NCT07667335Phase 1, Phase 21 site๐Ÿ“ Seattle Fred Hutchinson Cancer Center ยท Tests: Quemliclustat, Biospecimen Collection, Computed Tomography, Enfortumab Vedotin, Magnetic Resonance Imaging Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors NCT05706129Phase 1, Phase 210 sites๐Ÿ“ Melbourne๐Ÿ“ Sydney๐Ÿ“ Clermont-Ferrand Lumara Bio Oncologics GmbH ยท Tests: [68Ga]Ga-DPI-4452, [177Lu]Lu-DPI-4452 9MW2821 + Toripalimab vs 9MW2821 for 1st Line Locally Advanced or Metastatic Urothelial Carcinoma NCT06823427Phase 22 sites๐Ÿ“ Changsha๐Ÿ“ Nanjing Mabwell (Shanghai) Bioscience Co., Ltd. ยท Tests: 9MW2821, Toripalimab (JS001 ) Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer NCT07421700Phase 1, Phase 2184 sites๐Ÿ“ Fayetteville๐Ÿ“ Rogers๐Ÿ“ Springdale Pfizer ยท Tests: PF-08634404, Enfortumab Vedotin Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancer NCT04878029Phase 11 site๐Ÿ“ Atlanta Emory University ยท Tests: Cabozantinib S-malate, Enfortumab Vedotin, Quality-of-Life Assessment, Questionnaire Administration A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract NCT07218380Phase 3276 sites๐Ÿ“ Tucson๐Ÿ“ Little Rock๐Ÿ“ Irvine Eli Lilly and Company ยท Tests: Vepugratinib, Placebo, EV, Pembrolizumab KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04) NCT07232602Phase 1, Phase 217 sites๐Ÿ“ San Francisco๐Ÿ“ Chicago๐Ÿ“ New York Merck Sharp & Dohme LLC ยท Tests: MK-3120, EV, Pembrolizumab, Rescue Medication Dual-Target Nectin-4/HER2 CAR-NK Cells in Advanced Urothelial Carcinoma NCT07492628Phase 11 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: EB-DT-NK-UC101, Cyclophosphamide, Fludarabine A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2 NCT04879329Phase 2221 sites๐Ÿ“ Gilbert๐Ÿ“ Gilbert๐Ÿ“ Anaheim Seagen, a wholly owned subsidiary of Pfizer ยท Tests: disitamab vedotin, pembrolizumab
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