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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Malignant Solid Neoplasm

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment NCT05661461Phase 12 sites๐Ÿ“ San Antonio๐Ÿ“ West Valley City Aadi Bioscience, Inc. ยท Tests: nab-sirolimus ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR) NCT06415487Phase 19 sites๐Ÿ“ San Diego๐Ÿ“ Denver๐Ÿ“ Nashville Acepodia Biotech, Inc. ยท Tests: Cyclophosphamide, Fludarabine, ACE2016, Pembrolizumab CD8 PET Imaging in Metastatic Solid Tumours NCT06534190Phase 24 sites๐Ÿ“ Amsterdam๐Ÿ“ Groningen๐Ÿ“ Barcelona University Medical Center Groningen ยท Tests: 89Zr-Df-crefmirlimab PET scan, Nivolumab, Cetrelimab, zirconium Zr 89 crefmirlimab berdoxam Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors NCT04879121Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Larotrectinib Sulfate A Study With ABL103 in Subjects With Advanced or Metastatic Solid Tumors NCT06126666Phase 13 sites๐Ÿ“ Seongnam๐Ÿ“ Seoul๐Ÿ“ Seoul ABL Bio, Inc. ยท Tests: ABL103 Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors NCT04777994Phase 130 sites๐Ÿ“ Tucson๐Ÿ“ New Haven๐Ÿ“ Baltimore Calico Life Sciences LLC ยท Tests: ABBV-CLS-484, Vascular Endothelial Growth Factor Receptor (VEGFR) Tyrosine Kinase Inhibitor (TKI), Programmed Cell Deatโ€ฆ Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Avapritinib Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer NCT04511039Phase 11 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate DBC-664 in Adult Patients With Solid Tumors NCT07705035Phase 16 sites๐Ÿ“ Denver๐Ÿ“ Grand Rapids๐Ÿ“ East Brunswick Duboce Biopharmaceuticals, Inc. ยท Tests: DBC-664 A Study of RC118 in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors NCT05205850Phase 1, Phase 22 sites๐Ÿ“ Shanghai๐Ÿ“ Hangzhou RemeGen Co., Ltd. ยท Tests: RC118-ADC A Clinical Trial to Evaluate Effect of IBD0333 in Patients With Advanced Malignant Tumors NCT06292208Phase 1, Phase 21 site๐Ÿ“ Jinan SUNHO๏ผˆChina๏ผ‰BioPharmaceutical CO., Ltd. ยท Tests: IBD0333 A Study of AP402 in HER2-Positive Patients With Locally or Advanced Solid Tumors NCT06669975Phase 1, Phase 23 sites๐Ÿ“ Macquarie๐Ÿ“ Bedford Park๐Ÿ“ Perth AP Biosciences Inc. ยท Tests: AP402 (Part 1 Dose esclation), AP402 (Part 2 Dose Expansion) A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) NCT05118789Phase 1, Phase 263 sites๐Ÿ“ Orange๐Ÿ“ Palo Alto๐Ÿ“ Sacramento Nuvalent Inc. ยท Tests: Zidesamtinib (NVL-520) PE0116 and PE0105 Injection in Treatment of Patients With Advanced Solid Tumor NCT05801237Phase 1, Phase 21 site๐Ÿ“ Shanghai Shanghai HyaMab Biotech Co.,Ltd. ยท Tests: PE0116&PE0105 A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors NCT07105215Phase 1, Phase 239 sites๐Ÿ“ Beijing๐Ÿ“ Fuzhou๐Ÿ“ Fuzhou RemeGen Co., Ltd. ยท Tests: RC278 Study of IBI3005 in Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumors NCT06418061Phase 11 site๐Ÿ“ Jinan Innovent Biologics (Suzhou) Co. Ltd. ยท Tests: IBI3005 Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors NCT06545942Phase 118 sites๐Ÿ“ Goodyear๐Ÿ“ La Jolla๐Ÿ“ San Francisco MOMA Therapeutics ยท Tests: MOMA-313, Olaparib A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-6452 in Adult Patients With Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Advanced/Metastatic Breast Cancer or Locally Advanced/Metastatic Solid Tumor NCT07612891Phase 1, Phase 21 site๐Ÿ“ Shanghai Shenzhen Ionova Life Sciences Co., Ltd. ยท Tests: INV-6452 FOG-001 in Locally Advanced or Metastatic Solid Tumors NCT05919264Phase 1, Phase 233 sites๐Ÿ“ Phoenix๐Ÿ“ Scottsdale๐Ÿ“ Tucson Parabilis Medicines, Inc. ยท Tests: FOG-001, mFOLFOX-6, Nivolumab, Trifluridine/tipiracil, Bevacizumab Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors NCT05053971Phase 1, Phase 23 sites๐Ÿ“ New Haven๐Ÿ“ Gainesville๐Ÿ“ Oklahoma City National Cancer Institute (NCI) ยท Tests: BET Bromodomain Inhibitor ZEN-3694, Computed Tomography, Core Biopsy, Entinostat Imaging of Solid Tumors Using 18F-TRX NCT06942104Phase 11 site๐Ÿ“ San Francisco Rahul Aggarwal ยท Tests: 18F-TRX, Positron Emission Tomography (PET)/Computerized tomography (CT), Tumor Biopsy, Blood Specimen Collection A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer NCT06184035Phase 1, Phase 22 sites๐Ÿ“ Adelaide๐Ÿ“ Melbourne Spago Nanomedical AB ยท Tests: [177Lu]Lu-SN201 Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites๐Ÿ“ Seoul๐Ÿ“ Seoul๐Ÿ“ Seoul Yuhan Corporation ยท Tests: YH32364 First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors NCT07284186Phase 110 sites๐Ÿ“ Scottsdale๐Ÿ“ Duarte๐Ÿ“ Orange Plexium, Inc. ยท Tests: PLX-61639 Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer NCT05098210Phase 11 site๐Ÿ“ Seattle Fred Hutchinson Cancer Center ยท Tests: Neoantigen Peptide Vaccine, Nivolumab, Poly ICLC, Echocardiography Test, Multigated Acquisition Scan Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer NCT07137416Phase 12 sites๐Ÿ“ Boston๐Ÿ“ St Louis National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Echocardiography Test, Multigated Acquisition Scan, Pidnarulex A Clinical Trial to Evaluate Effect of IBB0979 in Patients With Advanced Malignant Tumors NCT05991583Phase 1, Phase 21 site๐Ÿ“ Shanghai SUNHO๏ผˆChina๏ผ‰BioPharmaceutical CO., Ltd. ยท Tests: IBB0979 The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) NCT04585750Phase 1, Phase 276 sites๐Ÿ“ Irvine๐Ÿ“ La Jolla๐Ÿ“ Los Angeles PMV Pharmaceuticals, Inc ยท Tests: rezatapopt, pembrolizumab Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors NCT05732831Phase 1, Phase 226 sites๐Ÿ“ Palo Alto๐Ÿ“ Grand Junction๐Ÿ“ Lake Mary Tango Therapeutics, Inc. ยท Tests: TNG462, Pembrolizumab
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