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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Rectal Cancer

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer NCT06307548Phase 1, Phase 21 site📍 Buffalo Roswell Park Cancer Institute · Tests: Aminolevulinic Acid, Biospecimen Collection, Computed Tomography, Fluorescence-Guided Surgery, Magnetic Resonance Imagi… Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC NCT07448077Phase 21 site📍 Shijiazhuang Hebei Medical University Fourth Hospital · Tests: Experimental: short-course radiotherapy and immunotherapy, Chemoradiotherapy Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma NCT05752136Phase 31 site📍 Hangzhou Sir Run Run Shaw Hospital · Tests: Envafolimab Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer NCT07458529Phase 21 site📍 Beijing Seventh Medical Center of PLA General Hospital · Tests: CRT+PD-1 inhibitor+Probio-M9, CRT+PD-1 inhibitor+placebo Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy NCT05965531Phase 21 site📍 Guangzhou Sun Yat-sen University · Tests: Trifluridine/Tipiracil, intensity-modulated radiotherapy Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer NCT06613165n/a1 site📍 Xi'an Xijing Hospital Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine As Conversion Therapy of Locally Advanced Colorectal Cancer NCT06405139Phase 21 site📍 Beijing Cancer Institute and Hospital, Chinese Academy of Medical S… · Tests: Nanoliposomal Irinotecan, Oxaliplatin plus Capecitabine Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT) NCT07026422Phase 21 site📍 Jinan Shandong Cancer Hospital and Institute · Tests: Total neoadjuvant therapy integrating iparomlimab/tuvonralimab with chemoradiotherapy Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Avapritinib Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors NCT04165772Phase 210 sites📍 Hartford📍 Miami📍 Basking Ridge Memorial Sloan Kettering Cancer Center · Tests: TSR-042 or Dostarlimab, capecitabine or 5-FU, Intensity Modulated Radiation Therapy (IMRT) CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer NCT06281405Phase 21 site📍 Shanghai Fudan University · Tests: PD-1 inhibitor, Capecitabine, Short-course radiotherapy, Oxaliplatin Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. NCT06940388Phase 22 sites📍 Mainz📍 Petah Tikva brenner baruch · Tests: Tislelizumab, Total neoadjuvant therapy (TNT) Short-course Radiotherapy (5×6Gy/7Gy/8Gy) Followed by Neo-adjuvant Chemotherapy for Locally Advanced Rectal Cancer NCT03466424n/a1 site📍 Fuzhou Fujian Medical University Union Hospital · Tests: preoperative short-course radiotherapy Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer NCT06765616Phase 21 site📍 Jinan Feng Tian · Tests: Adebrelimab Injection combined with radiotherapy and chemotherapy Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer NCT05972655Phase 21 site📍 Hanzhou Sir Run Run Shaw Hospital · Tests: Modified short-course radiotherapy, PD-1 antibody, Capecitabine, Oxaliplatin Intestinal Microbiome Modulation With Antibiotics in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer NCT06793137Phase 21 site📍 São Paulo AC Camargo Cancer Center · Tests: Metronidazole Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC NCT07646639Phase 21 site📍 Nanjing The First Affiliated Hospital with Nanjing Medical Universi… · Tests: Sintilimab + IL-2 Combined with CAPOX, Short-course low-dose radiotherapy, Short-course standard-dose radiotherapy mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC NCT06791512Phase 31 site📍 Guangzhou Jun Huang · Tests: mFOLFOX6 + Bevacizumab + PD-1 monoclonal antibody, mFOLFOX6 Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma NCT05772481n/a1 site📍 Strasbourg Centre Paul Strauss · Tests: PET-MRI SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer NCT05300269Phase 21 site📍 Shanghai Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Tests: SHR-1701；Capecitabine；Oxaliplatin Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT) NCT06770270Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Pucotenlimab Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer NCT04511039Phase 11 site📍 Buffalo Roswell Park Cancer Institute · Tests: Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate Hyperthermia With Chemoradiotherapy in Rectal Cancer NCT06831981NA2 sites📍 Tübingen📍 Tübingen University Hospital Tuebingen · Tests: Hyperthermia, Radiotherapy, Chemotherapy with 5-fluorouracil, Consolidation chemotherapy with FOLFOX SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC NCT07198165Phase 21 site📍 Shanghai Ruijin Hospital · Tests: PD-1 inhibitor based immunotherapy A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors NCT07376707Phase 11 site📍 Shanghai Hefei TG ImmunoPharma Co., Ltd. · Tests: TGI-5 A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types NCT07503808Phase 115 sites📍 Denver📍 Sarasota📍 Detroit IDEAYA Biosciences · Tests: IDE034 Neoadjuvant Treatment of Fulzerasib Plus Cetuximab N01 in KRAS G12C Mutated Locally Advanced Colorectal Cancer With or Without Resectable Metastases NCT07581912Phase 21 site📍 Hangzhou Zhejiang University · Tests: fulzerasib; cetuximab N01 SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer NCT05576480Phase 21 site📍 Shanghai Ruijin Hospital · Tests: Short-course radiotherapy, Penpulimab, CAPEOX, TME surgery UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer NCT05148767Phase 41 site📍 Hangzhou Zhejiang Cancer Hospital · Tests: Neoadjuvant chemoradiotherapy based on irinotecan A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC NCT07255664Phase 1, Phase 21 site📍 Frankfurt CuraCell TX AB · Tests: CC-38, Pembrolizumab, Cyclophosphamid, Interleukin-2, Uromitexan
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