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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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28 recruiting trials

for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma

Adebrelimab ยฑInduction Chemotherapy Followed by Concurrent Chemoradiotherapy for Unresectable Locally Advanced ESCC NCT06510660Phase 21 site๐Ÿ“ Fuzhou Fujian Medical University Union Hospital ยท Tests: adebrelimab Immunotherapy in Combination With Chemoradiotherapy in Unresectable Locally Advanced Esophageal Cancer NCT06173986Phase 1, Phase 21 site๐Ÿ“ Shanghai Shanghai Chest Hospital ยท Tests: PD-1inhibitor, nab-paclitaxel + cisplatin, Radiotherapy A Phase II Clinical Study of Sintilimab Combined with Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC) (NICE-CS) NCT06709417Phase 21 site๐Ÿ“ Shanghai Shanghai Chest Hospital ยท Tests: Sintilimab, Chemotherapy, radiotherapy A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) NCT07405151Phase 1, Phase 232 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: I-DXd, Rescue Medication A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCC NCT07733180Phase 24 sites๐Ÿ“ Yokohama๐Ÿ“ Takatsukishi๐Ÿ“ ChuoKu BeOne Medicines ยท Tests: Tislelizumab, Oxaliplatin, Leucovorin, 5-fluorouracil (5-FU) A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors NCT05592626Phase 1, Phase 219 sites๐Ÿ“ Sacramento๐Ÿ“ Celebration๐Ÿ“ Miami Marengo Therapeutics, Inc. ยท Tests: STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere) Neoantigen Vaccines in Esophageal Squamous Cell Carcinoma NCT06675201Phase 21 site๐Ÿ“ Chengdu Sichuan University ยท Tests: neoantigen-loaded dendritic cell vaccine (NeoDC-Vac) A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States NCT07554521Phase 29 sites๐Ÿ“ Bullhead City๐Ÿ“ Cerritos๐Ÿ“ Los Angeles BeOne Medicines ยท Tests: Tislelizumab, Capecitabine, 5-fluorouracil (5-FU), Oxaliplatin, Leucovorin Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC. NCT06452602Phase 21 site๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: Induction immunochemotherapy followed by Adebrelimab plus concurrent chemoradiotherapy, Induction immunochemotherapy foโ€ฆ Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) NCT06780111Phase 1, Phase 250 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: Pembrolizumab, I-DXd, Leucovorin, Levoleucovorin, 5-Fluorouracil (5-FU) Hypofractionated vs. Conventional Chemoradiotherapy After Induction Chemo-immunotherapy for Unresectable Esophageal Squamous Cell Carcinoma NCT06912074Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Induction chemoimmunotherapy, Hypofractionated Radiation Therapy, Conventional Fractionated Radiation Therapy, Concurreโ€ฆ Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab Intensive Nutritional Support in Conversion Therapy for Locally Advanced Unresectable ESCC NCT07519486Phase 21 site๐Ÿ“ Chengdu Sichuan University ยท Tests: PD-1 Inhibitor plus Chemotherapy, Oral Enteral Nutritional Preparation, Esophagectomy with lymph node dissection Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma NCT06988956Phase 21 site๐Ÿ“ Nanjing The First Affiliated Hospital with Nanjing Medical Universiโ€ฆ ยท Tests: Nimotuzumab, Tegafur, radiotherapy A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid Tumors NCT07730021Phase 1, Phase 24 sites๐Ÿ“ Lake Success๐Ÿ“ Fairfax๐Ÿ“ Chuo-ku Astellas Pharma Global Development, Inc. ยท Tests: ASP388B, Pembrolizumab, Carboplatin, Oxaliplatin, 5-fluorouracil A Study of BL-B01D1 in Combination With Tislelizumab ยฑ5-Fluorouracil Versus Platinum-Based Chemotherapy Plus Tislelizumab as First-line Treatment in Patients With Unresectable, Locally Advanced Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus02) NCT07554456Phase 2, Phase 31 site๐Ÿ“ Beijing Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-B01D1, Tislelizumab, 5-Fluorouracil, Cisplatin, Paclitaxel Efficacy and Safety of Tislelizumab Plus Chemotherapy as Conversion Therapy in Unresectable Locally Advanced ESCC NCT07549100n/a1 site๐Ÿ“ Jinan Shandong Provincial Hospital ยท Tests: Tislelizumab Plus Chemotherapy Surufatinib in Combination With Neoadjuvant Chemo-immunotherapy and Concurrent Chemoradiotherapy for Patients With Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma NCT07086469Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Neoadjuvant immunochemotherapy, Surufatinib Administration, Concurrent Chemotherapy, Radiotherapy Comparing ICI Followed By CCRT And CCRT Followed By Immunotherapy In Unresectable LA-ESCC NCT07733830Phase 27 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Zhengzhou Tianjin Medical University Cancer Institute and Hospital ยท Tests: Adebrelimab, Nab paclitaxel, Carboplatin, radiation Induction Chemo-Immunotherapy + Radiotherapy vs Concurrent Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma NCT07559045Phase 21 site๐Ÿ“ Zunyi Second Affiliated Hospital of Zunyi Medical University ยท Tests: Paclitaxel plus Cisplatin or Carboplatin (Induction Chemotherapy), Weekly Paclitaxel plus Cisplatin or Carboplatin (Conโ€ฆ Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer NCT04415853Phase 31 site๐Ÿ“ Beijing Sunshine Lake Pharma Co., Ltd. ยท Tests: Lerotinib, Irinotecan/Tegafur Nimotuzumab Concurrent With Chemoradiotherapy for Patients With Unresectable Esophageal Squamous Cell Carcinoma NCT06410651Phase 21 site๐Ÿ“ Beijing Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: Nimotuzumab with chemoradiotherapy Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program NCT06265285Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Home Health Encounter, Nivolumab, Patient Monitoring, Questionnaire Administration Short-Course Definitive Chemoradiotherapy Combined With Adjuvant or Concurrent Plus Adjuvant Camrelizumab for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma NCT07530094Phase 21 site๐Ÿ“ Nanjing Ning Jiang, M.D./Ph.D. ยท Tests: Camrelizumab Study of Tislelizumab Combined With Chemoradiotherapy and Surgery for Unresectable Esophageal Squamous Cell Carcinoma NCT07039162Phase 28 sites๐Ÿ“ Kaohsiung City๐Ÿ“ Kaohsiung City๐Ÿ“ Taichung Ming-Yu Lien ยท Tests: Tislelizumab, Paclitaxel, Cisplatin, Radiation Therapy Stratified Treatment in Unresectable Locally Advanced ESCC Without Progression After Chemoimmunotherapy Induction Plus CCRT: Toripalimab Consolidation vs observation--a Prospective, Randomized, Controlled Phase III Multicenter Study NCT07246330Phase 31 site๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: Toripalimab Exploratory Clinical Trial of Oral Paclitaxel Plus Radiotherapy in Patients With Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma NCT07435454Phase 21 site๐Ÿ“ Nanjing Jiangsu Cancer Institute & Hospital ยท Tests: oral paclitaxel+radiotherapy Oncolytic Virus in Esophageal Squamous Cell Carcinoma NCT07061704Phase 1, Phase 21 site๐Ÿ“ Chengdu Sichuan University ยท Tests: Oncolytic Virus: Administered via intratumoral injection (metastatic lesions in the neck or supraclavicular lymph nodesโ€ฆ
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