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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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25 recruiting trials

for Locally Advanced or Metastatic Malignant Solid Tumors

Study of IBI3005 in Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumors NCT06418061Phase 11 site๐Ÿ“ Jinan Innovent Biologics (Suzhou) Co. Ltd. ยท Tests: IBI3005 A Study of ASP2998 Given by Itself and Given With Standard Therapies in People With Solid Tumors NCT07287995Phase 1, Phase 29 sites๐Ÿ“ Celebration๐Ÿ“ Hackensack๐Ÿ“ New Hyde Park Astellas Pharma Global Development, Inc. ยท Tests: ASP2998, Pembrolizumab, Enfortumab Vedotin, Carboplatin Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor Diagnosis NCT05059678NA1 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Best Practice, Educational Intervention, Questionnaire Administration A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC288 in the Treatment of Solid Tumors NCT07537881Phase 1, Phase 214 sites๐Ÿ“ Hunan๐Ÿ“ Sichuan๐Ÿ“ Fujian RemeGen Co., Ltd. ยท Tests: RC288 For Injection, RC288 For Injection DBC-664 in Adult Patients With Solid Tumors NCT07705035Phase 17 sites๐Ÿ“ Denver๐Ÿ“ Grand Rapids๐Ÿ“ St Louis Duboce Biopharmaceuticals, Inc. ยท Tests: DBC-664 A Clinical Trial to Evaluate Effect of IBB0979 in Patients With Advanced Malignant Tumors NCT05991583Phase 1, Phase 21 site๐Ÿ“ Shanghai SUNHO๏ผˆChina๏ผ‰BioPharmaceutical CO., Ltd. ยท Tests: IBB0979 Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors NCT04879121Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Larotrectinib Sulfate A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors NCT07105215Phase 1, Phase 239 sites๐Ÿ“ Beijing๐Ÿ“ Fuzhou๐Ÿ“ Fuzhou RemeGen Co., Ltd. ยท Tests: RC278 A Clinical Trial to Evaluate Effect of IBD0333 in Patients With Advanced Malignant Tumors NCT06292208Phase 1, Phase 21 site๐Ÿ“ Jinan SUNHO๏ผˆChina๏ผ‰BioPharmaceutical CO., Ltd. ยท Tests: IBD0333 Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer NCT05705492Phase 21 site๐Ÿ“ Portland OHSU Knight Cancer Institute ยท Tests: Olanzapine, Placebo Administration, Questionnaire Administration A Study of SIM0689 in Adult Participants With Locally Advanced or Metastatic Solid Tumors NCT07660432Phase 16 sites๐Ÿ“ Fuzhou๐Ÿ“ Zhengzhou๐Ÿ“ Changsha Jiangsu Simcere Pharmaceutical Co., Ltd. ยท Tests: SIM0689 for Injection GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors NCT06265025Phase 1, Phase 24 sites๐Ÿ“ Goyang-si๐Ÿ“ Seoul๐Ÿ“ Seoul GeneMedicine Co., Ltd. ยท Tests: GM103 (Part A), GM103 (Part B), GM103 and Pembrolizumab (Part C) Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial NCT05564377Phase 2484 sites๐Ÿ“ Birmingham๐Ÿ“ Mobile๐Ÿ“ Anchorage National Cancer Institute (NCI) ยท Tests: Alpelisib, Binimetinib, Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration A Study of RC118 in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors NCT05205850Phase 1, Phase 22 sites๐Ÿ“ Shanghai๐Ÿ“ Hangzhou RemeGen Co., Ltd. ยท Tests: RC118-ADC The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) NCT04585750Phase 1, Phase 276 sites๐Ÿ“ Irvine๐Ÿ“ La Jolla๐Ÿ“ Los Angeles PMV Pharmaceuticals, Inc ยท Tests: rezatapopt, pembrolizumab Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer NCT05098210Phase 11 site๐Ÿ“ Seattle Fred Hutchinson Cancer Center ยท Tests: Neoantigen Peptide Vaccine, Nivolumab, Poly ICLC, Echocardiography Test, Multigated Acquisition Scan Adapting Treatment to the Tumor Molecular Alterations for Patients With Advanced Solid Tumors: MyOwnSpecificTreatment NCT02029001Phase 27 sites๐Ÿ“ Bordeaux๐Ÿ“ Lyon๐Ÿ“ Lyon Centre Leon Berard ยท Tests: Nilotinib (400 mg BID), Everolimus (10 mg QD), Sorafenib (400 mg BID), Lapatinib (1500 mg QD), Pazopanib (800 mg QD) Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer NCT04511039Phase 11 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression NCT06051695Phase 1, Phase 212 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B694, A2B543, xT CDx with HLA-LOH Assay Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors NCT05269381Phase 1, Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab, Sargramostim, Biospecimen Collection A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy NCT06362369Phase 1, Phase 25 sites๐Ÿ“ Aurora๐Ÿ“ Lake Mary๐Ÿ“ Lebanon 7 Hills Pharma, LLC ยท Tests: Alintegimod, Ipilimumab, Nivolumab A Study of TAK-505 in Adults With Solid Tumors NCT07436728Phase 1, Phase 215 sites๐Ÿ“ Orange๐Ÿ“ San Diego๐Ÿ“ San Francisco Takeda ยท Tests: TAK-505 A Study of RC148 As a Single Agent and Combination Therapy in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors NCT06016062Phase 1, Phase 231 sites๐Ÿ“ Anhui๐Ÿ“ Beijing๐Ÿ“ Beijing RemeGen Co., Ltd. ยท Tests: RC148 Monotherapy, RC148+docetaxel Combination Therapy, RC148+RC48 Combination Therapy, RC148+RC88 Combination Therapy,โ€ฆ Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Avapritinib Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors NCT06364410Phase 11 site๐Ÿ“ Houston National Cancer Institute (NCI) ยท Tests: Azenosertib, Biopsy Procedure, Biospecimen Collection, Computed Tomography, Echocardiography Test
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