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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Combination Study of Antibiotics With Enzalutamide (PROMIZE) NCT06126731Phase 1, Phase 22 sites📍 Bellinzona📍 Sutton Institute of Cancer Research, United Kingdom · Tests: Enzalutamide 40mg, Amoxicillin 500mg, Metronidazole 400mg, Vancomycin 125mg, Ciprofloxacin 500g Sipuleucel-T Combined With Bipolar Androgen Therapy in Men With mCRPC NCT06100705Phase 21 site📍 New Haven Yale University · Tests: Testosterone Cypionate, Sipuleucel-T First-Time-in-Human Study of GSK5471713 in Adults With mCRPC NCT07332455Phase 1, Phase 216 sites📍 La Jolla📍 Grand Rapids📍 Philadelphia GlaxoSmithKline · Tests: GSK5471713 A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma NCT03460977Phase 185 sites📍 Tucson📍 Tucson📍 Tucson Pfizer · Tests: Mevrometostat (PF-06821497), Enzalutamide, Itraconazole Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients NCT06615752Phase 1, Phase 21 site📍 Los Angeles Charles Drew University of Medicine and Science · Tests: green tea and quercetin + docetaxel, Placebo + docetaxel Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection NCT05413850Phase 1, Phase 221 sites📍 Miami📍 Miami📍 Atlanta Blue Earth Therapeutics Ltd · Tests: Lutetium (177Lu) rhPSMA-10.1 Injection, 18F-rhPSMA-7.3 injection (in phase 1 only) A Study in Patients With Metastatic Castration-Resistant Prostate Cancer NCT07719361Phase 110 sites📍 Los Angeles📍 Boston📍 Boston Flare Therapeutics Inc. · Tests: FX-111 Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) NCT06353386Phase 1, Phase 277 sites📍 La Jolla📍 Los Angeles📍 Miami Merck Sharp & Dohme LLC · Tests: Opevesostat, Olaparib, Docetaxel, Cabazitaxel, Fludrocortisone acetate Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) NCT06136624Phase 3288 sites📍 Orange📍 Palo Alto📍 Riverside Merck Sharp & Dohme LLC · Tests: Opevesostat, Abiraterone acetate, Enzalutamide, Hydrocortisone, Fludrocortisone acetate Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer NCT07002320Phase 1, Phase 24 sites📍 Bellinzona📍 Belfast📍 Cambridge Institute of Cancer Research, United Kingdom · Tests: SX-682, Apalutamide Docetaxel or Cabazitaxel With or Without Darolutamide in mCRPC NCT05762536Phase 21 site📍 Rotterdam Erasmus Medical Center · Tests: Darolutamide, Docetaxel or cabazitaxel RC48 Monotherapy or Combination With Envafolimab for CDK12 Alterations mCRPC With Standard Treatment Failure NCT06663007Phase 1, Phase 21 site📍 Tianjin Tianjin Medical University Second Hospital · Tests: RC48, Envafolimab A Phase 3 Study of [177Lu]Ludotadipep for Metastatic Castration-Resistant Prostate Cancer NCT07853209Phase 38 sites📍 Gyeonggi-do📍 Seoul📍 Seoul FutureChem · Tests: [177-Lu]Ludotadipep, Best supportive care/standard of care (BSC/SOC) alone Study of Allogeneic Anti-PSMA CAR-NK Cell for Metastatic Castration-Resistant Prostate Cancer NCT07156045EARLY Phase 11 site📍 Beijing Cancer Institute and Hospital, Chinese Academy of Medical S… · Tests: anti-PSMA CAR-NK A Phase I Clinical Study of HLX3902 in Patients With mCRPC and Other Advanced Tumours NCT07533708Phase 15 sites📍 Nanchang📍 Naning📍 Nanjing Shanghai Henlius Biotech · Tests: HLX3902 REGN15505 (PSMAx4-1BB) Alone or in Combination With Cemiplimab or REGN4336 (PSMAxCD3) in Adult Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell Carcinoma NCT07594106Phase 1, Phase 26 sites📍 Goodyear📍 Duarte📍 Tampa Regeneron Pharmaceuticals · Tests: REGN15505, REGN15505+Cemiplimab, REGN15505+REGN4336 Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors NCT05283330Phase 18 sites📍 Chicago📍 Iowa City📍 Lexington Orano Med Theranostics, SAS · Tests: ²¹²Pb-DOTAM-GRPR1 Radiotherapy Combined With Fluzopanib and Abiraterone Acetate Tablets (II) Treatment for mCRPC NCT06971211Phase 21 site📍 Shenyang Jianbin Bi · Tests: Intensity-modulated radiation therapy (IMRT) in combination with fluzoparib, abiraterone acetate tablets (II), and pred… A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors NCT03972657Phase 1, Phase 224 sites📍 Gilbert📍 Phoenix📍 Tucson Regeneron Pharmaceuticals · Tests: REGN5678, Cemiplimab A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004) NCT06136650Phase 3330 sites📍 Tucson📍 Irvine📍 Los Angeles Merck Sharp & Dohme LLC · Tests: Opevesostat, Dexamethasone, Fludrocortisone acetate, Hydrocortisone, Abiraterone acetate A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer NCT04729114Phase 125 sites📍 Tucson📍 Anaheim📍 Santa Rosa Astellas Pharma Global Development, Inc. · Tests: PRL-02 injection, prednisone, dexamethasone, enzalutamide A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer. NCT06629779Phase 3231 sites📍 Chandler📍 Gilbert📍 Glendale Pfizer · Tests: PF-06821497, Placebo, Enzalutamide Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer NCT06190899Phase 1, Phase 213 sites📍 Detroit📍 Clermont-Ferrand📍 Marseille Celcuity Inc · Tests: Gedatolisib, Darolutamide Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer NCT05113537Phase 1, Phase 21 site📍 San Francisco Vadim S Koshkin · Tests: Abemaciclib, Lutetium Lu 177-PSMA-617 Study With [225Ac]Ac-FL-020 in mCRPC Participants NCT06492122Phase 111 sites📍 Duarte📍 Irvine📍 Stanford Full-Life Technologies UK Limited · Tests: [225Ac]Ac-FL-020, Blood samples for PK, [111In]In-FL-020, Blood and urine samples collection, SPECT/CT images Observational Study on Lutetium (177Lu) Vipivotide Tetraxetan to Treat Metastatic Castration Resistant Prostate Cancer NCT07093801n/a34 sites📍 Alessandria📍 Asti📍 Bergamo Novartis Pharmaceuticals HER2 FPBMC in Patients With Metastatic Breast and Prostate Cancer (AM006) NCT07441889Phase 1, Phase 21 site📍 Charlottesville University of Virginia · Tests: HER2 FPBMC Autologous Gamma Delta T Cells to Target Prostate Stem Cell Antigen in mCRPC NCT06193486Phase 11 site📍 Tampa H. Lee Moffitt Cancer Center and Research Institute · Tests: MSGV1-PSCA-8T28Z, Fludarabine, Cyclophosphamide A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC) NCT07164443Phase 3174 sites📍 La Jolla📍 Los Angeles📍 Los Angeles Janssen Research & Development, LLC · Tests: Pasritamig, Placebo, Best Supportive Care (BSC), JNJ-87189401 A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas NCT04104776Phase 1, Phase 280 sites📍 Tampa📍 Atlanta📍 Chicago Novartis Pharmaceuticals · Tests: Tulmimetostat, Enzalutamide
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