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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Metastatic Gastroesophageal Junction Adenocarcinoma

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors NCT05733000Phase 21 site๐Ÿ“ Chicago Northwestern University ยท Tests: Biospecimen Collection, Computed Tomography, Devimistat, Fluorouracil, Gemcitabine Hydrochloride First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2) NCT06730373Phase 220 sites๐Ÿ“ Zhengzhou๐Ÿ“ Binzhou๐Ÿ“ Dongying Qilu Hospital of Shandong University ยท Tests: Disitamab Vedotin, Sintilimab, S-1, Trastuzumab, Oxaliplatin Ph1b/2 Study of the Safety and Efficacy of SHR-A1811 Combinations in Advanced HER2 Expression Gastric Cancer NCT05671822Phase 21 site๐Ÿ“ Shanghai Suzhou Suncadia Biopharmaceuticals Co., Ltd. ยท Tests: SHR-A1811 and SHR-1701, SHR-A1811 and capecitabine, SHR-A181, SHR-1701, and capecitabine, SHR-A1811, SHR-1316, and capeโ€ฆ A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer NCT05365581Phase 146 sites๐Ÿ“ Orange๐Ÿ“ Santa Monica๐Ÿ“ Chicago Astellas Pharma Global Development, Inc. ยท Tests: ASP2138, Pembrolizumab, Oxaliplatin, Leucovorin, Fluorouracil KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy NCT05427383Phase 2, Phase 31 site๐Ÿ“ Beijing Shanghai JMT-Bio Inc. ยท Tests: KN026/Placbo Injection, Paclitaxel Injection, Docetaxel Injection, Irinotecan Injection Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Avapritinib Apatinib as the First-Line Therapy in Elderly Locally Advanced or Metastatic Gastric Cancer NCT03219593Phase 21 site๐Ÿ“ Bengbu The First Affiliated Hospital of Bengbu Medical University ยท Tests: Apatinib mesylate tablets BC001 in Combination with Sintilimab and XELOX in the Treatment of HER-2 Negative Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma. NCT06773312Phase 11 site๐Ÿ“ Beijing Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd. ยท Tests: BC001+Sintilimab+XELOX Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2) NCT07432295Phase 26 sites๐Ÿ“ Goodyear๐Ÿ“ Duarte๐Ÿ“ Boston I-Mab Biopharma US Limited ยท Tests: Givastomig, Nivolumab, 5Fluorouracil, Leucovorin, Oxaliplatin Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer NCT04511039Phase 11 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate DBC-664 in Adult Patients With Solid Tumors NCT07705035Phase 16 sites๐Ÿ“ Denver๐Ÿ“ Grand Rapids๐Ÿ“ East Brunswick Duboce Biopharmaceuticals, Inc. ยท Tests: DBC-664 A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors NCT07488676Phase 1, Phase 221 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ Miami Astellas Pharma Global Development, Inc. ยท Tests: ASP546C Capeox Regimen Combined With Sintilimab and Bevacizumab for Gastric Cancer NCT05640609Phase 1, Phase 21 site๐Ÿ“ Chengdu West China Hospital ยท Tests: Capeox regimen combined with Sintilimab and Bevacizumab QLS31905 in Combination With CAPOX Versus Sintilimab in Combination With CAPOX as First-line Treatment in Patients With GC/GEJ NCT07716449Phase 31 site๐Ÿ“ Beijing Qilu Pharmaceutical Co., Ltd. ยท Tests: QLS31905, Sintilimab, Oxaliplatin, Capecitabine Fruquintinib in Combination With Sintilimab and CAPEOX as First-line Treatment for G/GEJ Cancer NCT06329973Phase 1, Phase 21 site๐Ÿ“ Zhengzhou Henan Cancer Hospital ยท Tests: Fruquintinib in combination with Sintilimab and CAPEOX A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors NCT06657144Phase 130 sites๐Ÿ“ Tucson๐Ÿ“ Duarte๐Ÿ“ Aurora Coherus Oncology, Inc. ยท Tests: CHS-114, Toripalimab, 5 Fluorouracil, Cisplatin A Phase Ib/II Study of Adebrelimab in Combination with Capecitabine and Oxaliplatin in Cancer NCT06776770Phase 1, Phase 21 site๐Ÿ“ Shenzhen Cancer Hospital Chinese Academy of Medical Science, Shenzheโ€ฆ ยท Tests: Adebrelimab IBI343 Combined With Sintilimab Plus Chemotherapy in Gastric Cancer NCT07025889Phase 1, Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: IBI343, Sintilimab, Oxaliplatin, S-1 LM-302 and S-1 Plus Intraperitoneal Paclitaxel With or Without Cadonilimab for Claudin 18.2-positive Gastric or Gastroesophageal Junction Adenocarcinoma With Peritoneal Metastasis: a Prospective, Exploratory Study NCT07556640Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: LM-302, S-1, paclitaxel, LM-302, Cadonilimab, S-1, paclitaxel Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers NCT04221893NA2 sites๐Ÿ“ San Francisco๐Ÿ“ Walnut Creek University of California, San Francisco ยท Tests: Radiation Therapy (RT) Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer NCT07392892Phase 2, Phase 3102 sites๐Ÿ“ Atascadero๐Ÿ“ Burbank๐Ÿ“ Encino Pfizer ยท Tests: PF-08634404, Chemotherapy, Nivolumab Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study NCT05753306Phase 21 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Cisplatin, Computed Tomography, Gastrectomy, Magnetic Resonance Imaging, Positron Emission Tomography A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma NCT07043400Phase 395 sites๐Ÿ“ Chandler๐Ÿ“ Los Alamitos๐Ÿ“ Colorado Springs BeOne Medicines ยท Tests: Subcutaneous Tislelizumab, Intravenous Tislelizumab, Cisplatin, Leucovorin, 5-fluorouracil (5-FU) Tislelizumab Plus FOLFOX Versus POF in the Treatment of Locally Advanced: a Multicenter, Open-label, Randomized Phase III Studyunresectable or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma NCT06793917Phase 31 site๐Ÿ“ Fuzhou Fujian Cancer Hospital ยท Tests: Tislelizumab, Oxaliplatin injection, Levo-Leucovorin, 5-fluorouracil, Paclitaxel Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas NCT07546812Phase 215 sites๐Ÿ“ Boston๐Ÿ“ Boston๐Ÿ“ Albany Gilead Sciences ยท Tests: Denikitug, Nivolumab, Ramucirumab, Paclitaxel Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors NCT04900818Phase 121 sites๐Ÿ“ Orange๐Ÿ“ Aurora๐Ÿ“ Layfayette I-Mab Biopharma US Limited ยท Tests: TJ033721 (givastomig), TJ033721 (givastomig) , nivolumab, chemotherapy, TJ033721 (givastomig), chemotherapy, TJ033721 (โ€ฆ Phase II Trial of Iparomlimab/Tuvonralimab (QL1706) + XELOX in HER2-Negative, Low PD-L1 G/GEJ Adenocarcinoma NCT06932068Phase 229 sites๐Ÿ“ Zhengzhou๐Ÿ“ Binzhou๐Ÿ“ Dezhou Qilu Hospital of Shandong University ยท Tests: Iparomlimab and Tuvonralimab (QL1706), Oxallplation, Capectitabine Tablets A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. NCT06902545n/a15 sites๐Ÿ“ Goyang-si๐Ÿ“ Suwon๐Ÿ“ Suwon Astellas Pharma Korea, Inc. ยท Tests: zolbetuximab Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer NCT06962137Phase 26 sites๐Ÿ“ Antwerp๐Ÿ“ Brussels๐Ÿ“ Brussels Universitaire Ziekenhuizen KU Leuven ยท Tests: zolbetuximab, Retrospective cohort, no intervention Albumin-bound Paclitaxel-based Second-line Treatment Regimens for Locally Advanced or Metastatic G/GEJ Adenocarcinoma NCT07389876n/a1 site๐Ÿ“ Shanghai Fudan University ยท Tests: Albumin-bound Paclitaxel, Immune Checkpoint Inhibitor, Anti-angiogenic drug, Trastuzumab emtansine
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