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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Myelodysplastic Syndromes, High Risk

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse NCT06928662Phase 1, Phase 21 site📍 Seattle Fred Hutchinson Cancer Center · Tests: Decitabine, Bone Marrow Aspiration, Bone Marrow Biopsy, Chest Radiography, Cytarabine Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome NCT00801489Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Cytarabine, Decitabine, Filgrastim-sndz, Fludarabine Phosphate, Gemtuzumab Ozogamicin Efficacy of Immediate Allogeneic Hematopoietic Stem Cell Transplantation Versus Bridging Therapy Followed by Transplantation in Higher-Risk Myelodysplastic Syndrome Patients NCT06918834Phase 25 sites📍 Beijin📍 Zhengzhou📍 Jinan Institute of Hematology & Blood Diseases Hospital, China · Tests: Immediate HSCT Group, Bridging Therapy Group CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia NCT03896269Phase 11 site📍 Houston M.D. Anderson Cancer Center · Tests: Liposome-encapsulated Daunorubicin-Cytarabine A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS. NCT04275518Phase 114 sites📍 Beijing📍 Guangzhou📍 Guangzhou Ascentage Pharma Group Inc. · Tests: APG-115, Azacitidine, Cytarabine Venetoclax Basket Trial for High Risk Hematologic Malignancies NCT05292664Phase 15 sites📍 San Francisco📍 Aurora📍 Atlanta Andrew E. Place, MD · Tests: Venetoclax, Azacitidine, Cytarabine, Methotrexate, Hydrocortisone Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS NCT04708054Phase 2, Phase 31 site📍 Houston M.D. Anderson Cancer Center · Tests: Busulfan, Cladribine, Fludarabine Phosphate, Hematopoietic Cell Transplantation, Thiotepa Clinical Study of Azacitidine Combined With Ruxolitinib in the Treatment of Higher-risk MDS/MPN NCT05817955Phase 21 site📍 Nanjing The First Affiliated Hospital with Nanjing Medical Universi… · Tests: Azacitidine (AZA) with Ruxolitinib MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies NCT05735717Phase 21 site📍 Minneapolis Masonic Cancer Center, University of Minnesota · Tests: Fludarabine, Busulfan, Melphalan, Rituximab, Levetiracetam Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome NCT07582172Phase 21 site📍 Duarte City of Hope Medical Center · Tests: Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography, Echocardiography Test, Fludarabine Phosphate Sonrotoclax Plus Azacitidine in Patients With MDS-IB2 NCT07885397Phase 1, Phase 26 sites📍 Shanghai📍 Shanghai📍 Shanghai Shanghai General Hospital, Shanghai Jiao Tong University Sc… · Tests: Sonrotoclax, Azacitidine (AZA) HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML NCT06594445Phase 11 site📍 Minneapolis Masonic Cancer Center, University of Minnesota · Tests: GTB-360 Monitoring Minimal Residual Disease of Patients With Acute Myelogenous Leukemia or High Grade Myelodysplastic Syndrome NCT01311258n/a1 site📍 Rochester University of Rochester Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy NCT03630991Phase 11 site📍 Houston M.D. Anderson Cancer Center · Tests: Edetate Calcium Disodium, Multivitamin, Succimer SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) NCT03113643Phase 13 sites📍 Duarte📍 Boston📍 Houston Dana-Farber Cancer Institute · Tests: Azacitidine, SL-401, Venetoclax 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome NCT06287944Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Actinium Ac 225-DOTA-Daratumumab, Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomograp… A Study Testing an Improved Dose of UM171 to Help Make Cord Blood Transplants More Effective and Safe. NCT07301866Phase 1, Phase 21 site📍 Montreal Ciusss de L'Est de l'Île de Montréal · Tests: ECT-001-CB First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS) NCT07384715Phase 16 sites📍 Aarhus📍 Copenhagen📍 Barcelona Genmab · Tests: GEN3018 Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies NCT07044544Phase 11 site📍 Birmingham University of Alabama at Birmingham · Tests: G-CSF, Decitabine, Venetoclax Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders NCT04644016Phase 21 site📍 New York Memorial Sloan Kettering Cancer Center · Tests: Clofarabine, Fludarabine, Busulfan, Cyclosporine-A, Mycophenolate Mofetil Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome NCT03661307Phase 1, Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Decitabine, Quizartinib, Venetoclax A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome NCT06501196Phase 113 sites📍 Duarte📍 Los Angeles📍 Palo Alto BlossomHill Therapeutics · Tests: BH-30236, Venetoclax Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia NCT02115295Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Cladribine, Cytarabine, Gilteritinib, Idarubicin, Laboratory Biomarker Analysis Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With High-risk Myeloid Malignancies and a Partially Mismatched Donor NCT07238712Phase 21 site📍 Saint Petersburg St. Petersburg State Pavlov Medical University · Tests: Ruxolitinib, Abatacept (Orencia) Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia NCT03214562Phase 1, Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Cytarabine, Filgrastim, Fludarabine, Idarubicin, Pegfilgrastim Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4). NCT06641414Phase 3155 sites📍 Birmingham📍 Phoenix📍 Los Angeles Ascentage Pharma Group Inc. · Tests: Lisaftoclax (APG-2575), Azacitidine Injection, Placebo Personalized NK Cell Therapy in CBT NCT02727803Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Allogeneic Natural Killer Cell Line NK-92, Anti-Thymocyte Globulin, Busulfan, Clofarabine, Cyclophosphamide Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies NCT07523555Phase 1, Phase 21 site📍 Shenzhen Beijing Biotech · Tests: Autologous CD19/CD22 dual-target CAR-T module, Autologous CD19/CD20 dual-target CAR-T module, Autologous BCMA/CD19 dual… Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation NCT07573111Phase 11 site📍 Palo Alto Laguna Biotherapeutics, Inc. · Tests: QUAIL-100 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia NCT03128034Phase 1, Phase 21 site📍 Seattle Fred Hutchinson Cancer Center · Tests: Cyclosporine, Fludarabine Phosphate, Mycophenolate Mofetil, Peripheral Blood Stem Cell Transplantation, Pretargeted Rad…
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