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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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28 recruiting trials

for Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) NCT07209189Phase 21 site📍 Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Tests: Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell Carcinoma NCT07497607Phase 21 site📍 Cincinnati Sara Medek · Tests: Cisplatin, Radiotherapy Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma NCT03875716NA1 site📍 Boston Dana-Farber Cancer Institute · Tests: Radiation therapy De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) NCT06307015NA1 site📍 Saint Leonards Royal North Shore Hospital · Tests: De-escalation, Standard of care A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer NCT06319963Phase 1, Phase 24 sites📍 Orlando📍 Tampa📍 Tampa Theravectys S.A. · Tests: Two IM injections Lenti-HPV-07, One IM injection Lenti-HPV-07 Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) NCT06088381Phase 25 sites📍 Baltimore📍 Baltimore📍 Bel Air University of Maryland, Baltimore · Tests: Experimental Observation, Observation per Standard of Care, Adjuvant Treatment per Standard of Care, Circulating Tumor … Intranasal WSK-IM05 Vaccine Plus Tislelizumab as Neoadjuvant Therapy for HPV+ OPSCC NCT07565740Phase 11 site📍 Chengdu West China Hospital · Tests: WSK-IM05 (4×10^10 vp), WSK-IM05 (8×10^10 vp), WSK-IM05 (1.6x10^11 vp), Tislelizumab CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs NCT07172256Phase 21 site📍 New Haven Yale University · Tests: CUE-101, Pembrolizumab Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma, PAP-OP Study NCT06115772n/a1 site📍 Rochester Mayo Clinic · Tests: Non-Interventional Study Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery NCT06747390Phase 11 site📍 Philadelphia Ryan Carey · Tests: Lidocaine 1% Injectable Solution ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx NCT06915038NA2 sites📍 Carmel📍 Indianapolis Indiana University · Tests: NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer NCT06563479Phase 39 sites📍 Hartford📍 Miami📍 Basking Ridge Memorial Sloan Kettering Cancer Center · Tests: FMISO-PET Scan, Chemoradiation, Chemoradiation, Assessments The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial) NCT05419089Phase 22 sites📍 Paramus📍 New York Icahn School of Medicine at Mount Sinai · Tests: Robotic surgery De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA NCT05541016Phase 23 sites📍 Scottsdale📍 Jacksonville📍 Rochester Mayo Clinic · Tests: Biospecimen Collection, Cisplatin, Computed Tomography, Diffusing Alpha-emitter Radiation Therapy, Docetaxel Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus NCT05918510n/a1 site📍 Rome Regina Elena Cancer Institute · Tests: Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx NCT05600842n/a1 site📍 Orange University of California, Irvine · Tests: Intensity-Modulated Radiation Therapy (IMRT) E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers NCT05639972Phase 1, Phase 22 sites📍 New Brunswick📍 New Brunswick Christian Hinrichs · Tests: E7 TCR-T cells, Aldesleukin Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial NCT06636734Phase 22 sites📍 Atlanta📍 Atlanta Emory University · Tests: Biospecimen Collection, Computed Tomography, Lovastatin, Magnetic Resonance Imaging, Pembrolizumab E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers NCT05686226Phase 23 sites📍 Bethesda📍 New Brunswick📍 New Brunswick Christian Hinrichs · Tests: E7 TCR-T cells, Aldesleukin A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) NCT07063212Phase 27 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: Sacituzumab Govitecan, Cetuximab Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma NCT03215719Phase 21 site📍 New York NYU Langone Health · Tests: Standard Radiation Treatment, Dose-Deescalated Treatment, Cisplatinum Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma NCT06016920Phase 1, Phase 212 sites📍 Montpellier📍 Paris📍 Giessen Nykode Therapeutics ASA · Tests: VB10.16, Pembrolizumab Monitoring and Early Response Evaluation Using HPV DNA - A Study on Patients With HPV-positive Throat Cancer (MER-HPV) NCT05649865n/a1 site📍 Lund Region Skane · Tests: Blood sample A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC) NCT05307939Phase 28 sites📍 Miami📍 Basking Ridge📍 Middletown Memorial Sloan Kettering Cancer Center · Tests: HPV ctDNA Assay, MRI Studies, EORTC QLQ H&N 35 and C30, MDADI-HN, COST-FACIT Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study NCT04900623Phase 22 sites📍 Boston📍 Boston Jonathan Schoenfeld, MD, MPH · Tests: NavDx HPV ctDNA Testing, Radiotherapy, Chemotherapy drug Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer NCT04444869Phase 21 site📍 Columbia University of Missouri-Columbia · Tests: Cisplatin injection A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects With HPV Positive HNSCC. NCT06797986Phase 1, Phase 22 sites📍 Seoul📍 Seoul Cellid Co., Ltd. · Tests: BVAC-E6E7 (low level), BVAC-E6E7 (high level), BVAC-E6E7 (RP2D) De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas NCT03396718NA10 sites📍 Tübingen📍 Essen📍 Dresden Technische Universität Dresden · Tests: De-escalation radio(chemo)therapy - Level 1, De-escalation radio(chemo)therapy - Level 2, Standard radio(chemotherapy)
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