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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Primary Central Nervous System Lymphoma (PCNSL)

Combination Regimen of Teniposide, PD-1 Monoclonal Antibody and Selinixor for Patients With Relapsed or Refractory PCNSL NCT07074470NA1 site📍 Suzhou The First Affiliated Hospital of Soochow University · Tests: Induction therapy-2 cycles of VPX (Teniposide, PD-1 monoclonal antibody plus Selinixor), Consolidation therapy with ASC… Orelabrutinib Combined With Pemetrexed For Relapsed/Refractory Central Nervous System Lymphoma NCT05209620Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: ICP-022, Pemetrexed Q702 for the Treatment of Patients With Hematologic Malignancies NCT06712810Phase 12 sites📍 Scottsdale📍 Rochester Mayo Clinic · Tests: Axl/Mer/CSF1R Inhibitor Q702, Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma NCT05625594Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Aspiration, Biospecimen Collection, Catheterization, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem T-lymphocytes, Comput… Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL NCT07185373Phase 2, Phase 315 sites📍 Beijing📍 Beijing📍 Chengdu Huashan Hospital · Tests: Teniposide, Orelabrutinib, MTX, Rituximab (R), Dexamethasone Rituximab-Methotrexate-Temozolomide-Thiotepa (RMTT) Regimen As First-line Therapy for PCNS DLBCL NCT06832267NA1 site📍 Hangzhou Zhejiang Cancer Hospital · Tests: Rituximab-Methotrexate-Temozolomide-Thiotepa (RMTT) Study of Lenalidomide/Rituximab Maintenance for Transplantation Ineligible Patients With PCNSL. NCT04627753Phase 21 site📍 Seoul Kim, Seok Jin · Tests: Rituximab, lenalidomide Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma NCT05256641Phase 1, Phase 23 sites📍 Los Angeles📍 Sacramento📍 Oklahoma City Jonsson Comprehensive Cancer Center · Tests: Acalabrutinib B-cell Mature Non-Hodgkin's Lymphoma Treatment Protocol in Children and Adolescents 2021 NCT05518383Phase 41 site📍 Moscow Federal Research Institute of Pediatric Hematology, Oncolog… · Tests: Cyclophosphamide, Cytarabine, Dexamethasone, Etoposide, Ifosfamide, Methotrexate, Cyclophosphamide, Cytarabine, Dexamet… [90Y]Y-PTT Endoradiotherapy in CNS Lymphoma Patients NCT06132737Phase 1, Phase 22 sites📍 Munich📍 Essen Pentixapharm AG · Tests: [90Y]Y-PentixaTher Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma NCT05351593Phase 1, Phase 21 site📍 San Francisco James Rubenstein · Tests: Tafasitamab, Lenalidomide Lenalidomide Maintenance Treatment in Patients With Primary Central Nervous System Lymphoma NCT05260619Phase 21 site📍 Seongnam-si Seoul National University Bundang Hospital · Tests: lenalidomide Registry of an Integrated Longitudinal Multimodal Biospecimen Biobank for Primary CNS Lymphoma in China NCT07842835n/a3 sites📍 Beijing📍 Shandong📍 Tianjin Xiaohui Ren · Tests: High-dose methotrexate-based therapy, Bruton tyrosine kinase inhibitor-based therapy Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL). NCT06213636Phase 1, Phase 21 site📍 Beijing Essen Biotech · Tests: CD19/CD22-CAR T cells R-PMDT Regimen in Newly Diagnosed PCNSL NCT07604987Phase 21 site📍 Tianjin Zou Dehui · Tests: R-PMDT CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL) NCT03328078Phase 1, Phase 245 sites📍 Phoenix📍 Phoenix📍 Duarte Curis, Inc. · Tests: Emavusertib, Ibrutinib A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL) NCT07082868Phase 18 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: ibrutinib, Epcoritamab High-Dose Gemcitabine, Busulfan, and Thiotepa Followed by ASCT in Primary Central Nervous System Lymphoma NCT07014943Phase 21 site📍 Chengdu Sichuan University · Tests: High dose Gemcitabine, Busulfan, and Thiotepa as conditioning therapy Rituximab, Methotrexate, and Tepadina Induction Followed by Etoposide and Cytarabine Consolidation in Primary Central Nervous System Lymphoma NCT06946407NA1 site📍 Changchun FengYan Jin · Tests: Rituximab, Methotrexate, and Thiotepa (R-MT) Induction Followed by Etoposide and Cytarabine (EA) Consolidation A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies NCT04830137Phase 116 sites📍 Duarte📍 Orange📍 San Francisco Nurix Therapeutics, Inc. · Tests: NX-2127 Anbalcabtagene Autoleucel in Relapsed/Refractory CNS Lymphoma NCT07062627Phase 21 site📍 Seoul Hyungwoo Cho · Tests: Anbal-cel Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma. NCT06263361n/a1 site📍 Milan IRCCS San Raffaele · Tests: MRI imaging, Cerebral biopsy A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies NCT05131022Phase 162 sites📍 Duarte📍 San Francisco📍 Denver Nurix Therapeutics, Inc. · Tests: NX-5948 The Study of the Combination of Thiotepa and Pomalidomide for the Treatment of Relapsed/Refractory Primary Central Nervous System Lymphoma Patients. NCT05931328Phase 21 site📍 Nanjing The First Affiliated Hospital with Nanjing Medical Universi… · Tests: thiotepa combined with pomalidomide Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL NCT04906096Phase 22 sites📍 Boston📍 Boston Lakshmi Nayak, MD · Tests: PAXALISIB A Study of Pomadomide in Combination With Rituximab and Methotrexate for Newly-diagnosed Primary Central Nervous System Lymphoma NCT06554561Phase 1, Phase 21 site📍 Hanzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Pomalidomide, Rituximab, Methotrexate Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas NCT05681195Phase 21 site📍 Miami Baptist Health South Florida · Tests: Pemetrexed, Zanubrutinib, Autologous Stem Cell Transplant (ASCT), Whole Brain Radiation Therapy (WBRT) NB02 (Poseltinib) Combined Rituximab and Lenalidomide in R/R PCNSL NCT06737250Phase 210 sites📍 Busan📍 Hwasun📍 Ilsan NOBO Medicine · Tests: R2P -> RP Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104) NCT06940791Phase 21 site📍 Tokyo Kyorin University · Tests: Tirabrutinib, Placebo Thiotepa in Combination With Pirtobrutinib (a BTK Inhibitor) and Sintilimab (a PD-1 Inhibitor) for Frail or Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma NCT07416890Phase 21 site📍 Hangzhou Zhejiang Cancer Hospital · Tests: Thiotepa, Pirtobrutinib , Sintilimab(TPS)
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