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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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21 recruiting trials

for Progressive Glioblastoma

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas NCT07003542Phase 21 site๐Ÿ“ Cleveland Case Comprehensive Cancer Center ยท Tests: Sitagliptin Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Intracranial Genetically Modified Immune Cells (TGFฮฒR2KO/IL13Rฮฑ2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial โ€ฆ Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas NCT07468136Phase 1, Phase 21 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Biospecimen Collection, Eflornithine, Lumbar Puncture, Magnetic Resonance Imaging, Retifanlimab Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma NCT06356883Phase 21 site๐Ÿ“ Sherbrooke Universitรฉ de Sherbrooke ยท Tests: IA Carboplatin + IA Caelyx, IA Carboplatin + IA Etoposide Phosphate A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) NCT04573140Phase 12 sites๐Ÿ“ Washington D.C.๐Ÿ“ Gainesville University of Florida ยท Tests: Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liโ€ฆ Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07551336Phase 11 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: Dual-target CAR-NK cells, Cyclophosphamide, Intracranial catheter/reservoir for locoregional delivery, Fludarabine A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma NCT07301268Phase 21 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Biospecimen Collection, Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102, Computed Tomography, Echocardiography Test,โ€ฆ ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial NCT07089641Phase 12 sites๐Ÿ“ Los Angeles๐Ÿ“ New York Jonsson Comprehensive Cancer Center ยท Tests: Biospecimen Collection, Echocardiography Test, EGFR Inhibitor ERAS-801, Fludeoxyglucose F-18, Magnetic Resonance Imaging Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma NCT07076472EARLY Phase 11 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Aminolevulinic Acid Intravenous Formulation SONALA-001, Biospecimen Collection, Computed Tomography, Electronic Health โ€ฆ Sitagliptin in Recurrent/Progressive Grade 4 Glioma NCT07541781Phase 11 site๐Ÿ“ Iowa City Kailin Yang, MD, PhD ยท Tests: Sitagliptin, Bevacizumab First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma NCT07560865Phase 11 site๐Ÿ“ Minneapolis Masonic Cancer Center, University of Minnesota ยท Tests: FT536, Biopsy/ Intratumoral Injection/ Gross Tumor Resection, Blood/ Cerebrospinal Fluid/ Tumor Pathology A Study to Evaluate Safety and Efficacy of BEY1107 in Combination with Temozolomide in Patients with Recurrent or Progressive Glioblastoma Multiforme (GBM) NCT05769660Phase 11 site๐Ÿ“ Seoul BeyondBio Inc. ยท Tests: BEY1107, Temozolomide A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma. NCT07779798Phase 14 sites๐Ÿ“ Duarte๐Ÿ“ Tampa๐Ÿ“ Houston Crossbow Therapeutics, Inc. ยท Tests: CBX-663 Study of Pembrolizumab and M032 (NSC 733972) NCT05084430Phase 1, Phase 21 site๐Ÿ“ Birmingham University of Alabama at Birmingham ยท Tests: M032, Pembrolizumab A Study of VRT106 for Injection in Patients With Recurrent/Progressive Glioblastoma NCT07093814Phase 1, Phase 211 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Chongqing Guangzhou Virotech Pharmaceutical Co., Ltd. ยท Tests: VRT106 Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. NCT05686798Phase 11 site๐Ÿ“ Detroit Henry Ford Health System ยท Tests: Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS) PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications NCT06161519Phase 1, Phase 21 site๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: PLX038 A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma NCT05765812Phase 1, Phase 216 sites๐Ÿ“ Chicago๐Ÿ“ New York๐Ÿ“ New York Debiopharm International SA ยท Tests: Debio 0123, Temozolomide, Radiotherapy Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07480941Phase 11 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: Dual-target CAR-NK cells, Cyclophosphamide, Fludarabine, Intracranial catheter/reservoir for locoregional delivery
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