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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Recurrent High-Grade Gliomas

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site📍 Boadilla del Monte Fundación de investigación HM · Tests: Olaparib; 177Lu-DOTATATE Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDG… Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial … Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas NCT05139056Phase 14 sites📍 Duarte📍 Stanford📍 Chicago City of Hope Medical Center · Tests: Neural Stem Cells-expressing CRAd-S-pk7, Resection NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NCT07664176Phase 11 site📍 Washington D.C. Children's National Research Institute · Tests: NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site📍 Bethesda National Institute of Neurological Disorders and Stroke (NI… · Tests: LMP744, Conventional Surgery or Biopsy MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas NCT06712875Phase 1, Phase 23 sites📍 Washington D.C.📍 Chicago📍 New York Ann & Robert H Lurie Children's Hospital of Chicago · Tests: Trametinib and Nivolumab, Dabrafenib, trametinib, nivolumab Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells NCT04254419Phase 11 site📍 Columbus Nationwide Children's Hospital · Tests: NK cells A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma NCT05698524Phase 11 site📍 Omaha University of Nebraska · Tests: PCI 24781, Temozolomide Study of Letrozole in Recurrent Gliomas NCT03122197EARLY Phase 11 site📍 Cincinnati University of Cincinnati · Tests: Letrozole Oral Tablet, Temozolomide CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site📍 Minneapolis OX2 Therapeutics · Tests: Treatment with CD200AR-L A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) NCT04573140Phase 12 sites📍 Washington D.C.📍 Gainesville University of Florida · Tests: Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP li… Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07551336Phase 11 site📍 Shenzhen Beijing Biotech · Tests: Dual-target CAR-NK cells, Cyclophosphamide, Intracranial catheter/reservoir for locoregional delivery, Fludarabine Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma NCT04590664Phase 1, Phase 21 site📍 Atlanta Emory University · Tests: Verteporfin A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. NCT07017816EARLY Phase 11 site📍 Washington D.C. Children's National Research Institute · Tests: SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection NCT06018363Phase 1, Phase 21 site📍 Suzhou Dushu Lake Hospital Affiliated to Soochow University · Tests: Allogenic B7-H3 CAR-γδT cell(QH104) Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma NCT07061626Phase 11 site📍 Chicago Cerenome · Tests: Rhenium-186 Nanoliposome [177Lu]Lu-DOTA-EB-RGD2 Therapy in Patients With Recurrent High-grade Glioma NCT07655869EARLY Phase 12 sites📍 Beijing📍 Beijing Beijing Tiantan Hospital · Tests: [177Lu]Lu-DOTA-EB-RGD2 ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma NCT05917145Phase 11 site📍 Rochester Mayo Clinic · Tests: WSD0628 Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559Phase 117 sites📍 Birmingham📍 Los Angeles📍 San Diego University of California, San Francisco · Tests: Everolimus, Trametinib A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites📍 Tampa📍 Chicago📍 New York Tetragon Biosciences Ltd · Tests: GLIX1 ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas NCT06838676Phase 220 sites📍 Aurora📍 Washington D.C.📍 Miami Nationwide Children's Hospital · Tests: ACT001 Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment NCT05460507Phase 11 site📍 San Antonio Cerenome · Tests: Retreatment Rhenium Liposome GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma NCT07301268Phase 21 site📍 Rochester Mayo Clinic · Tests: Biospecimen Collection, Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102, Computed Tomography, Echocardiography Test,… Evaluation of ex Vivo Drug Combination Optimization Platform in Recurrent High Grade Astrocytic Glioma NCT05532397NA2 sites📍 Singapore📍 Singapore National University Hospital, Singapore · Tests: QPOP category 1, QPOP category 2 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites📍 New York📍 Durham Duke University · Tests: MVR-C5252 DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma NCT06264388Phase 21 site📍 Miami Ashish Shah · Tests: DB107-RRV, DB107-FC A Phase I Clinical Study of Intratumoral Injection GC001 in Patient With Recurrent or Progressive Gliomas NCT06660056Phase 11 site📍 Beijing GONGCHU Biotechnology Co., Ltd · Tests: A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patient With Recurrent or Progress… Effect of Electroacupuncture Combined With Paclitaxel Clinical Efficacy of Patients With Recurrence of High-grade Glioma NCT06330337Phase 31 site📍 Zhejiang The Third Affiliated hospital of Zhejiang Chinese Medical U… · Tests: Temozolomide（TMZ） injection or oral administration, Albumin-Bound Paclitaxel(ABX) intravenous drip, Specific mode elect… Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) NCT05979064NA1 site📍 New York Northwell Health · Tests: Laparoscopically harvested omental tissue autograft
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