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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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19 recruiting trials

for Severe Sickle Cell Disease

Investigation of the Genetics of Hematologic Diseases NCT02720679n/a1 site๐Ÿ“ Memphis St. Jude Children's Research Hospital Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC NCT04528355n/a1 site๐Ÿ“ Pittsburgh Paul Szabolcs ยท Tests: data collection T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias NCT03653338Phase 1, Phase 21 site๐Ÿ“ Pittsburgh Paul Szabolcs ยท Tests: CD3/CD19 depleted leukocytes, CD45RA depleted leukocytes, Hydroxyurea, Rituximab, Alemtuzumab Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients NCT07000747n/a1 site๐Ÿ“ Pointe-ร -Pitre Centre Hospitalier Universitaire de la Guadeloupe Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders NCT03128996Phase 1, Phase 24 sites๐Ÿ“ New Haven๐Ÿ“ Wilmington๐Ÿ“ Grand Rapids Washington University School of Medicine ยท Tests: RIC regimen, GVHD prophylaxis regimen Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease NCT02447874Phase 1, Phase 22 sites๐Ÿ“ Atlanta๐Ÿ“ Atlanta Emory University ยท Tests: Arginine, Arginine (Loading), Arginine (Continuous) CS-206 in Patients With Sickle Cell Disease NCT06565026EARLY Phase 11 site๐Ÿ“ Nanning CorrectSequence Therapeutics Co., Ltd ยท Tests: CS-206 Optimizing Hydroxyurea Dosage With Pharmakokinetic in Patients Suffering of Moderate to Severe Sickle Cell Anemia NCT06761560Phase 2, Phase 31 site๐Ÿ“ Montreal Yves Pastore ยท Tests: Pharmacokinetic based dosage change, Pharmacokinetic dosing Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent ฮฒ-Thalassemia and Severe Sickle Cell Disease NCT05477563Phase 36 sites๐Ÿ“ New York๐Ÿ“ Charlotte๐Ÿ“ Nashville Vertex Pharmaceuticals Incorporated ยท Tests: CTX001 RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease NCT05392894Phase 31 site๐Ÿ“ London King's College Hospital NHS Trust ยท Tests: Haploidentical stem cell transplantation, Standard medical care Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies NCT05213572n/a1 site๐Ÿ“ Bethesda National Heart, Lung, and Blood Institute (NHLBI) Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor NCT03214354Phase 21 site๐Ÿ“ Calgary University of Calgary ยท Tests: Alemtuzumab, Total Body Irradiation, Sirolimus HPC Offered for PRESERVE Expansion NCT07145411n/a4 sites๐Ÿ“ Birmingham๐Ÿ“ Detroit๐Ÿ“ Columbus Ossium Health, Inc. ยท Tests: Bone Marrow Transplant with Ossium's HPC, Marrow (bone marrow recovered from deceased organ and tissue donors) Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease NCT04774536Phase 1, Phase 23 sites๐Ÿ“ Davis๐Ÿ“ Los Angeles๐Ÿ“ Oakland Mark Walters, MD ยท Tests: CRISPR_SCD001 Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease NCT04819841Phase 1, Phase 26 sites๐Ÿ“ Los Angeles๐Ÿ“ Palo Alto๐Ÿ“ St Louis Kamau Therapeutics ยท Tests: nula-cel Drug Product Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT NCT01962415Phase 21 site๐Ÿ“ Pittsburgh Paul Szabolcs ยท Tests: Hydroxyurea, Alemtuzumab, Fludarabine, Melphalan, Thiotepa Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe ฮฒ-Hemoglobinopathies NCT06647979Phase 11 site๐Ÿ“ Boston Daniel Bauer ยท Tests: autologous bone marrow derived CD34+ HSPCs electroporated with BCL11A enhancer targeting Cas9 ribonucleoprotein, Sequenโ€ฆ 131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD) NCT07015684Phase 11 site๐Ÿ“ New York Columbia University ยท Tests: 131I-apamistmab, Sirolimus, Campath, Total Body Irradiation, Exchange Transfusion AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion NCT04099966Phase 21 site๐Ÿ“ Valhalla Mitchell Cairo ยท Tests: alpha beta depletion
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