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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Treatment Resistant Major Depression

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. NCT05973851Phase 312 sites📍 Innsbruck📍 Bielefeld📍 Dortmund Dr. Inge Winter · Tests: Esketamine Nasal Product, Ketamine Hydrochloride, Esketamine hydrochloride, Second-line Antidepressants Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression NCT07226232Phase 35 sites📍 Birmingham📍 Tuscaloosa📍 Portland VA Office of Research and Development · Tests: Psilocybin, Psilocybin University of Iowa Interventional Psychiatry Service Patient Registry NCT04480918n/a1 site📍 Iowa City Mark Niciu · Tests: Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine, Esketamine, Deep Transcranial Magne… Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation NCT06542094NA1 site📍 Chengdu West China Hospital · Tests: Deep Brain stimulation Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) NCT04296097NA1 site📍 Grenoble University Hospital, Grenoble · Tests: DBS The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression NCT06163625NA1 site📍 Toronto Unity Health Toronto · Tests: Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan, Saliva Samples Maintenance rTMS for Depression (Maitr-De) NCT06938841NA3 sites📍 San Diego📍 New York📍 Canberra University of California, San Diego · Tests: Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS:, Transcranial Magnetic Stimulation (TMS) - Cluster… Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression NCT06396312n/a1 site📍 Munich Max-Planck-Institute of Psychiatry Psilocybin rTMS for Treatment Resistant Depression NCT06132178Phase 21 site📍 Austin University of Texas at Austin · Tests: Psilocybin, Accelerated intermittent theta burst (aiTBS) rTMS treatment, Low-dose psilocybin, Sham Accelerated intermit… Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) NCT06423430NA26 sites📍 Birmingham📍 Los Angeles📍 Los Angeles Abbott Medical Devices · Tests: Sham-stimulation, Active-stimulation ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response NCT07284667Phase 228 sites📍 Birmingham📍 Chino📍 Glendale ACADIA Pharmaceuticals Inc. · Tests: ACP-211, Placebo Interleaved TMS-fMRI in Ultra-treatment Resistant Depression NCT05813093NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: rTMS ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder NCT07474974NA1 site📍 Porto Polytechnic Institute of Porto · Tests: Repetitive transcranial magnetic stimulation (rTMS) Establishing Mobile Transcranial Magnetic Stimulation NCT06748209Phase 41 site📍 Charleston Medical University of South Carolina · Tests: Left prefrontal Transcranial Magnetic Stimulation (TMS), FDA cleared TMS for treating depression French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls NCT07881016NA17 sites📍 Besançon📍 Bordeaux📍 Brest Fondation FondaMental · Tests: 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) NCT07569198Phase 21 site📍 Toronto Joshua Rosenblat · Tests: Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression NCT07543328NA1 site📍 Taipei Taipei Veterans General Hospital, Taiwan · Tests: transcranial photobiomodulation One-Day cTBS Over the Precuneus NCT07758010NA1 site📍 Belmont Mclean Hospital · Tests: Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst sti… Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression NCT03973268Phase 11 site📍 Bethesda National Institute of Mental Health (NIMH) · Tests: Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions, Arm 1 and 2 Interventions Comorbid Obesity and Depression With an Anti-inflammatory Medication NCT06537921NA1 site📍 London King's College London · Tests: Minocycline 200mg Accelerated iTBS for Major Depression NCT07603804NA1 site📍 Istanbul Istanbul University - Cerrahpasa · Tests: Accelerated Intermittent Theta Burst Stimulation (iTBS) rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression NCT06511544NA1 site📍 Indianapolis Indiana University · Tests: Transcranial magnetic stimulation Physical Activity Program for TRD NCT06404320NA1 site📍 Toronto Unity Health Toronto · Tests: PA program - MoveU.HappyU Cannabidiol Oil for Treatment-Resistant Major Depression NCT07696871Phase 1, Phase 21 site📍 Tubarão Universidade do Sul de Santa Catarina · Tests: Full-spectrum CBD oil 100 mg/mL, Placebo oil (MCT oil) Biomarker-Guided Antidepressant Selection NCT07680140Phase 41 site📍 New York Weill Medical College of Cornell University · Tests: TMS, Ketamine qEEG Brain Signature of Depression & Neuromodulation-induced Recovery NCT06719427Phase 12 sites📍 North York📍 Toronto Sunnybrook Health Sciences Centre · Tests: Transcranial Magnetic Stimulation Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression NCT06511908Phase 21 site📍 Bethesda National Institute of Mental Health (NIMH) · Tests: (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg), Placebo Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium NCT07594483NA3 sites📍 Atlanta📍 Iowa City📍 Houston Motif Neurotech, Inc. · Tests: Motif XCS System Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression NCT07324070NA1 site📍 Prague Charles University, Czech Republic · Tests: Electroconvulsive therapy, Transcranial Magnetic Stimulation Characterizing Synaptic Density in Treatment Resistant Depression NCT03537794n/a1 site📍 Toronto Unity Health Toronto · Tests: PET scans
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