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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Treatment-resistant Depression (TRD)

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression NCT07226232Phase 35 sites📍 Birmingham📍 Tuscaloosa📍 Portland VA Office of Research and Development · Tests: Psilocybin, Psilocybin Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation NCT06542094NA1 site📍 Chengdu West China Hospital · Tests: Deep Brain stimulation A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial NCT07227103Phase 2, Phase 33 sites📍 Sarasota📍 West Palm Beach📍 Belmont NeuroRx, Inc. · Tests: Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS, Oral Placebo DBS for Depression NCT06096207Phase 11 site📍 Queens Northwell Health · Tests: Medtronic SenSight Directional DBS lead French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls NCT07881016NA17 sites📍 Besançon📍 Bordeaux📍 Brest Fondation FondaMental · Tests: 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression NCT07563868NA2 sites📍 Boston📍 Boston Massachusetts General Hospital · Tests: Psychedelic Integration Coaching Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression NCT07543328NA1 site📍 Taipei Taipei Veterans General Hospital, Taiwan · Tests: transcranial photobiomodulation One-Day cTBS Over the Precuneus NCT07758010NA1 site📍 Belmont Mclean Hospital · Tests: Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst sti… Accelerated iTBS for Major Depression NCT07603804NA1 site📍 Istanbul Istanbul University - Cerrahpasa · Tests: Accelerated Intermittent Theta Burst Stimulation (iTBS) Physical Activity Program for TRD NCT06404320NA1 site📍 Toronto Unity Health Toronto · Tests: PA program - MoveU.HappyU Cannabidiol Oil for Treatment-Resistant Major Depression NCT07696871Phase 1, Phase 21 site📍 Tubarão Universidade do Sul de Santa Catarina · Tests: Full-spectrum CBD oil 100 mg/mL, Placebo oil (MCT oil) Treatment Resistant Depression and Vagus Nerve Stimulation NCT05952674NA24 sites📍 Angers📍 Bordeaux📍 Caen Assistance Publique - Hôpitaux de Paris · Tests: Vagus Nerve Stimulation (VNS), Best Medical Treatment Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression NCT07094789NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Next Generation Dome Helmet (NGDH) Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression NCT07146503n/a5 sites📍 Genova📍 Genova📍 Chieti Riccardo Guglielmo · Tests: Esketamine (Intranasal Spray) Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression NCT07080723Phase 41 site📍 Aalborg Aalborg University Hospital · Tests: Algorithm guided treatment (AGT), Treatment as usual (TAU) Biomarker-Guided Antidepressant Selection NCT07680140Phase 41 site📍 New York Weill Medical College of Cornell University · Tests: TMS, Ketamine A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression NCT03887715NA101 sites📍 Birmingham📍 Huntsville📍 Burlingame LivaNova · Tests: Vagus Nerve Stimulation (VNS) Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression. NCT07843927Phase 39 sites📍 Berlin📍 Augsburg📍 Berlin Charite University, Berlin, Germany · Tests: Dehydroepiandrosterone (DHEA), Placebo Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression NCT07324070NA1 site📍 Prague Charles University, Czech Republic · Tests: Electroconvulsive therapy, Transcranial Magnetic Stimulation TACS on High-inflammatory and Refractory Depression NCT06812923NA1 site📍 Tianjin Tianjin Anding Hospital · Tests: transcranial Alternating Current Stimulation (tACS), Sham stimulation Characterizing Synaptic Density in Treatment Resistant Depression NCT03537794n/a1 site📍 Toronto Unity Health Toronto · Tests: PET scans DBS for TRD With the Medtronic Percept PC NCT05773755NA1 site📍 New York Helen Mayberg, MD · Tests: Medtronic Percept PC DBS system Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression NCT05798143NA1 site📍 Chieti ITAB - Institute for Advanced Biomedical Technologies · Tests: Accelerated Repetitive Transcranial Magnetic Stimulation Esketamine With or Without Integration Therapy for Treatment-Resistant Depression NCT07369102Phase 42 sites📍 San Juan📍 San Juan University of Puerto Rico · Tests: Esketamine hydrochloride (intranasal), Integration Therapy Ketamine Augmentation of ECT in Treatment-Resistant Depression NCT07088380Phase 31 site📍 Milan Università Vita-Salute San Raffaele · Tests: Ketamine Hydrochloride, Placebo Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD) NCT04080778NA1 site📍 Houston Joao L. DeQuevedo · Tests: magnetic seizure therapy (MST), electroconvulsive therapy (ECT) Personalized DBS Targeting for Treating Depression NCT06784388EARLY Phase 11 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Deep Brain Stimulation(DBS), Esketamine COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression NCT06895863NA3 sites📍 Glostrup Municipality📍 Hilleroed📍 Hvidovre Danish Research Centre for Magnetic Resonance · Tests: MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Device: MagVenture XP Orange Stimulator a… Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression NCT06773949NA1 site📍 Ottawa The Royal Ottawa Mental Health Centre · Tests: Theta burst stimulation Sensation Seeking and TMS Response in TRD NCT07889739n/a1 site📍 München Technical University of Munich · Tests: Transcranial Magnetic Stimulation (TMS)
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