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Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

Recruitingn/aAges 1 Year - 100 YearsAllNational Institute of Allergy and Infectious Dise…
NCT00001406 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions. Eosinophil counts often rise in response to allergies, asthma, and parasitic worm infections. They can also go up in uncommon autoimmune conditions and, rarely, in association with tumors. Elevated levels of these cells is called eosinophilia. Usually, eosinophilia causes no apparent symptoms, but in rare cases there may be local swelling and itching, allergic lung problems, heart disease or nerve damage caused by the release of toxic substances in these cells into body tissues. Patients 1 to 100 years of age with eosinophil counts greater than 750/ml or an abnormal accumulation of eosinophils in the skin or body tissues may be eligible for this study. All participants will have a thorough medical history, physical

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Male or female, aged 1-100 3. Ability of subject (or Legally Authorized Representative (LAR)) to understand and sign a written informed consent document Eosinophilic Patients only: 4. Documented peripheral blood count \>1500/mm3, tissue eosinophilia (abnormal accumulation of eosinophils in the skin or other body tissues) or suspected eosinophilic end organ involvement 5. Primary (non-NIH) physician for routine medical care Relatives only: 6. Extended family member of an eosinophilic participant on this protocol EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Any condition(s) or diagnosis, physical and/or psychological, that the investigator feels precludes the patient from participation in the study. Relatives only: 2. Females must not be pregnant
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What it tests

  • Not listed
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Where

1 site
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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