Evaluation, Treatment, and Follow-up of Patients With Lyme Disease

* INCLUSION CRITERIA: * Clinical diagnosis of active Lyme disease at the time of the initial NIH evaluation based on the CDC case definition. Study physician will review history to confirm probable cases. * Subjects must maintain a private physician for non-protocol related medical complaints and for emergency medical treatment required for these or other of their disorders. EXCLUSION CRITERIA: * Post treatment Lyme disease syndrome. * Unacceptably poor compliance, which, in the opinion of the investigator, would interfere with one's ability to study or provide quality medical care for the patient. ELIGIBILITY CRITERIA TO BE ASKED TO UNDERGO APHERESIS INCLUDE: * Age 18 years or above * Weight greater than 110 pounds * No known heart, lung, kidney disease, or bleeding disorders * Negative HIV, HCV and HBsAg serologies * Female subjects should not be pregnant or nursing * Adequate peripheral venous access Patients will have a CBC performed up to 2 weeks before the procedure. In order to be able to undergo the procedure, patient must fulfill all of the below: * Hemoglobin greater than 11 g/dL for males and greater than 10 g/dL for females * Platelets greater than 150 k/mm(3) * WBC greater than 3.5 x 10(3) uL * MCV above 80 Women who are able to conceive children must have a negative pregnancy test within 2 weeks before the procedure.