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Urinary Vitamin C Loss in Diabetic Subjects

Recruitingn/aAges 18 Years - 65 YearsAllNational Institute of Diabetes and Digestive and …
NCT00071526 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these are difficult to interpret due to lack of controlled vitamin C intake, inadequate sampling, lack of control subjects, or methodology uncertainties in vitamin C assay and sample processing. Consequently, it is unclear whether diabetic subjects truly have both low plasma and high urine vitamin C concentrations. We propose that low plasma vitamin C concentrations in diabetic subjects are due in part to inappropriate renal loss of vitamin C in these subjects but not in healthy controls. We will study nondiabetic controls and cohorts with diabetes. Vitamin C concentrations in plasma, RBCs, and urine will be measured in outpatients. In those willing to be admitted to th

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: To be included in the study, study subjects should be: * Aged 18-65 years. * Either: * Have no diagnosis of diabetes: "nondiabetic controls", or * Have a diagnosis in their medical history of either Type 1 or Type 2 diabetes EXCLUSION CRITERIA (for outpatient study, arm 1) Exclusion criteria will include the following: * Unable or unwilling to provide a signed and dated informed consent form * Unable or unwilling to comply with study procedures and lifestyle considerations EXCLUSION CRITERIA (for inpatient studies, arms 2 and 3) Study participants interested in participating in Arms 2 and/or 3 will be excluded from this further participation if they meet any of the following: * significant organ malfunction leading to clinical instability including liver disease, pulmonary disease, ischemic heart disease, heart failure, stroke, peripheral vascular disease, and anemia at investigator discretion * other serious or chronic illness; history of serious or chronic illness; coronary artery disease, or peripheral vascular disease resulting in clinical instability * pregnancy or lactation * presence of other conditions which, in the judgment of the investigators, can influence vitamin C metabolism or vitamin C renal handling
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What it tests

  • Not listed
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Where

1 site
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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