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Determinants of Warfarin Metabolism

RecruitingNAAges 20 Years - 50 YearsAllHadassah Medical Organization
NCT00162474 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The anticoagulant effect of warfarin varies greatly among individuals. Some of this variability is attributed to differences in the activity of CYP2C9, the predominant enzyme involved in the metabolism of S-warfarin. The present study is designed to define the differences in warfarin metabolism among healthy individuals carrying different CYP2C9 genotypes. In addition, the study will define the correlation between the phenytoin metabolic ratio, a marker of CYP2C9 activity in vivo, and warfarin metabolism.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age range of 20-50 years old * The absence of significant disease states Exclusion Criteria: * Known hypersensitivity to warfarin or phenytoin * Known hepersensitivity to penicillins or cephalosporins (Dicloxacillin part) * The presence of significant disease states * Regular use of drugs (including birth control pills)
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What it tests

  • Warfarin
  • Phenytoin
  • Losartan & Hydrochlorothiazide
  • Flurbiprofen
  • Siponimod
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Where

1 site
Hadassah Medical Organization
Jerusalem, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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