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Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Recruitingn/aAges any - 20 YearsAllEmory University
NCT00243776 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing cardiopulmonary bypass surgery * Patients undergoing surgery for repair of congenital heart disease such as ventricular septal defect or defective mitral or aortic valves. Exclusion Criteria: * Prior cardiac surgery * History of atrial fibrillation or other atrial arrhythmias prior to operation * History of heart failure
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What it tests

  • Not listed
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Where

1 site
Emory University School of Medicine
Atlanta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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