💬In plain words
What the trial is, and whether it could suit you
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be discovered that affect "common" diseases that have multi-gene architecture with variable penetrance such as breast cancer, diabetes mellitus, and coronary artery disease. This change took place because investigators now have the tools to illuminate the whole genome at once to discover the genetic variants responsible for different disease phenotypes through statistical differences between populations. Besides disease phenotypes, health can be considered a human phenotype that can be studied. Health is not merely the absence of disease but may be viewed as a dynamic ongoing interplay between the environment and the genome to maintain homeostasis. Individuals often
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
1. Age 80 years or older
2. Eligible for blood draw and/or saliva collection
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent
5. Be healthy or have mild medical conditions that may be associated with the normal aging process, including:
* Hypertension, well controlled (no more than 3 medications)
* Osteoporosis, Osteopenia and/or osteoarthritis
* Benign prostatic hypertrophy
* Cataracts, Glaucoma, Macular Degeneration
* Dyslipidemia
* Hypothyroidism
* Pre-diabetes/impaired fasting glucose (fasting blood glucose 100-126 mg/dL, if known)
Exclusion Criteria:
1. \< 80 years old
2. Participants have been previously enrolled in The Scripps Genebank Healthy Elderly Cohort
3. Treatment with any investigational agents or devices within thirty days preceding enrollment in the study.
4. Self-reported history or current diagnosis of significant chronic conditions including:
* Any Cancer (including polycythemia; excluding basal or squamous cell skin cancer).
* Coronary Artery Disease/Myocardial Infarction
* Stroke/TIA
* Deep Vein Thrombosis/Pulmonary Embolus
* Chronic Renal Disease/Hemodialysis
* Significant Auto-immune/Inflammatory conditions such as (Rheumatoid Arthritis, Lupus, Crohn's, etc.
* Alzheimer's/Parkinson's
* Diabetes (Hemoglobin A1C \> 6.5 % or fasting glucose \>126 mg/dL or treated with oral diabetic medication or insulin if known)
* Aortic or Cerebral Aneurysm
5. Currently taking any of the following medications on a regular basis:
* Oral chemotherapeutic agents (ex.: tamoxifen, doxorubicin, mitoxantrone, bleomycin)
* Anti-platelet agents, not including aspirin (ex.: clopidogrel/plavix, dipyridamole/aggrenox/persantine, ticlopidine/ticlid)
* Cholinesterase inhibitor for Alzheimer's disease (i.e. donepezil/Aricept)
* Insulin
6. Subject has a significant medical condition which, in the Investigator's opinion, may interfere with the patient's optimal participation in the study or would potentially confound interpretation of the individual's phenotype.
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