Molecular Analysis Of Solid Tumors

Inclusion Criteria: * Must have a suspected or known diagnosis of neuroblastoma, osteosarcoma, Ewing sarcoma family of tumor or soft tissue sarcoma based on the initial diagnostic workup and evidence of gross disease amenable to excision. Specimens may be collected at some or all of the following time points: initial biopsy, bone marrow aspiration procedures, tumor resection, and at time of possible relapse. * Patients with a diagnosis of retinoblastoma based on initial diagnostic workup and who require enucleation may be enrolled if there is no active therapeutic or biologic protocol for retinoblastoma. * The patient or his/her legal guardian, as appropriate, must provide written informed consent within 30 days of the removal of the first collection of tissue/bone marrow/blood sample for this protocol. * The patient is being seen at St. Jude Children's Research Hospital or at a collaborating institution. * Patients must be less than or equal to 25 years old at the time of enrollment. Exclusion Criteria: * Patient is known to be Hepatitis B, Hepatitis C and/or HIV positive.