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Defining the Brain Phenotype of Children With Williams Syndrome

Recruitingn/aAges 5 Years - 99 YearsAllNational Institute of Mental Health (NIMH)
NCT01132885 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: \- Little is known about how the brain changes during childhood and adolescence, how genes affect this process, or how the brains of people with 7q11.23 genetic variation change during this period. Researchers are interested in using magnetic resonance imaging to study how the brain changes in healthy children and children with 7q11.23 genetic variation, including Williams syndrome and 7q11.23 duplication syndrome. Objectives: \- To study developmental changes in the brains of healthy children and children who have been diagnosed with Williams syndrome,7q11.23 duplication syndrome, or other 7q11.23 genetic variation. Eligibility: * Healthy children and adolescents between 5 and 17 years of age. * Children and adolescents between 5 and 17 years of age who have been diagnosed with Williams syndrome, 7q11.23 duplication syndrome, or have other 7q11.23 genetic variation. De

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: For all participants, the following inclusion criteria will apply: 1. Greater than 5 years old. 2. Able to provide assent if below the age of 18, or consent if 18 years of age or older. Parents will provide consent for participants below the age of 18. For patients who do not have the capacity to provide informed consent, consent may be obtained from a guardian or the holder of the DPA. Additionally, 7q11.23 CNV participants must have a typical, 7q11.23 CNV or other genetic abnormality in the Williams syndrome critical region of chromosome 7q11.23, and control participants must have normal intelligence. EXCLUSION CRITERIA: For all participants who will participate in MRI scanning, the following exclusion criteria will apply: 1. Any chronic or acute medical condition severe enough to interfere with task performance or interpretation of MRI data. 2. Any medication that might interfere with task performance or interpretation of MRI data. 3. Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye or other body part, dental braces). 4. Pregnancy (a urine pregnancy test will be performed prior to all MRI procedures for all females of child-bearing potential. 5. NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy. For parents who will undergo blood draws only, they will not be able to participate if they have a condition that would make collecting blood unsafe.
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What it tests

  • Not listed
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Where

1 site
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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