🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Age and Insulin Resistance

RecruitingNAAges 60 Years - 80 YearsAllUniversity of Lausanne
NCT01224886 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the risk for type 2 diabetes and is a key feature of the metabolic syndrome. The elevated prevalence of obesity and type 2 diabetes in the older population has important consequences on the morbidity and mortality as well as on the economic burden on society. Controversy currently exists as to whether or not aging contributes to insulin resistance. Many potential factors confound the association between aging and insulin resistance, including obesity and physical inactivity. Ectopic lipid depositions, defined as an excess accumulation of triglycerides in non adipose tissues such as in the liver (intrahepatic lipids) and within the muscle fibers (intramyocellular lipids), are positively associat

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age 60-80 * Sedentary or highly trained * BMI 18-40 * Non-Smoker * Normal glucose tolerance or impaired glucose tolerance * Willingness to comply with the protocol Exclusion Criteria: * Contraindication to moderate exercise or clinical conditions precluding from joining an exercise program, such as clinically significant cardiovascular disease, peripheral vascular disease, uncontrolled hypertension, neurological or orthopedic disease * Recent weight loss or weight gain * Known diabetes * Known drugs to affect glucose homeostasis such as nicotinic acid, glucocorticoids * Severe anemia or lipid disturbances, hepatic or renal disease * Recent history of cancer * Hypothyroidism * Recent hormone replacement therapy * Known allergy to lidocaine or other local anesthetic * Positive stress test * Active alcohol or substance abuse
💊

What it tests

  • Physical activity
📍

Where

2 sites
University of Bern
Bern, Switzerland
UNIL and CHUV
Lausanne, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy