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Sympathetic Overactivity in Post-traumatic Stress Disorder

RecruitingNAAges 18 Years - 65 YearsAllEmory University
NCT01627301 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension. One potential mechanism is overactivation of the sympathetic nervous system (SNS), both at rest and particularly during stress. This study will evaluate whether 8 weeks of daily DGB therapy or transcutaneous vagus nerve stimulation (tVNS) therapy improves SNS activity at rest and during stress.

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📋 Eligibility rules (as published)
Inclusion Criteria: * prehypertensive and normotensive veterans with PTSD, and prehypertensive and normotensive veterans without PTSD (controls) Exclusion Criteria: * heart or vascular disease * illicit drug use within the last 6 months * excessive alcohol use (\>2 drinks per day) * pregnancy * autonomic dysfunction * medications known to affect SNS (clonidine) * treatment with monoamine oxidase (MAO) inhibitors within the last 14 days * any serious systemic disease
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What it tests

  • Device-Guided Breathing (DGB)
  • Sham DGB
  • Transcutaneous Vagal Nerve Stimulation (tVNS)
  • Sham tVNS
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Where

1 site
Atlanta VA Medical Center
Decatur, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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