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COsegregation of VARiants in Panel of Genes

RecruitingNAAges 18 Years - anyAllInstitut Curie
NCT01689584 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: Index cases: * A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned. * Age ≥ 18 years. * Signed written inform consent "index case" Related parties: * Any relative of an index case with cancer * Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case * For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care. * Age ≥ 18 years * Information and signature of the informed consent "selected relatives" Exclusion Criteria: * Minors * Persons deprived of liberty or under guardianship (including curators). * Absence of signed written inform consent
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What it tests

  • salivary kit
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Where

62 sites
Centre Hospitalier de Bastia
Bastia, France
Institut Curie - Saint-Cloud site
Saint-Cloud, France
CHU Amiens - Hôpital Nord
Amiens, France
ICO - Centre Paul Papin
Angers, France
Centre Hospitalier d'Angoulème
Angoulême, France
Institut Sainte-Catherine
Avignon, France
CHU Besançon
Besançon, France
Groupe Hospitalier Pellegrin
Bordeaux, France

…and 54 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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