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Predictive Value of Neovascularization Within Asymptomatic Carotis Stenosis on CEUS

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT01732523 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atherosclerosis is a chronic, systemic and progressive disease affecting different arterial blood vessels in the body. Atherosclerotic lesions silently progress from small plaques to severe stenosis and may remain asymptomatic for years. Unstable plaques and stenosis (also called vulnerable plaques), however, are prone to rupture leading to myocardial infarction, or stroke. The proliferation of the small arteries that are distributed to the outer and middle coats of the larger blood vessels (vasa vasorum) and within the atherosclerotic plaques (neovascularization) are inherently linked with the atherosclerotic plaque development, plaque inflammation and vulnerability. By injecting ultrasound contrast agents (microbubbles) into the blood stream, it is possible to detect this microcirculation of the vessel wall and the neovascularization within the atherosclerotic plaque using a contrast-e

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients age \> 18 years * Asymptomatic (no history of cerebrovascular event in the corresponding vessel territory) ≥30% carotid stenosis on standard carotid ultrasound Exclusion Criteria: * History of previous carotid endarterectomy or carotid stenting. * Heart failure (HYHA III or IV) * Myocardial infarction (\<7d) * Severe pulmonal-arterial hypertension (pulmonal arterial pressure \>90mmHg) based on clinical information (history of pulmonal arterial pressure, dyspnea on exertion New York Heart Association (NYHA) III and NYHA IV) * pregnancy (pregnancy test in patients of childbearing age: \<50 years and/or less than 2 years after menopause) * Follow-up is not considered feasible
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What it tests

  • Contrast enhanced carotid ultrasound
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Where

1 site
Unversity Hospital Basel, Angiology
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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