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โ† Trials
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Nottingham Community Liver Biomarkers Cohort

Recruitingn/aAges 18 Years - anyAllUniversity of Nottingham
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In plain words

What the trial is, and whether it could suit you

Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom. The majority of liver disease is lifestyle related (alcohol, obesity and associated type 2 diabetes, injecting drug use) and therefore reversible if caught at a precirrhosis stage. However, current liver function blood tests are poor inadequate, and subsequently a large burden of liver disease is currently missed. A variety of noninvasive liver biomarkers (blood and imaging tests) have been developed which identify liver disease accurately at earlier stages of scarring. The identification of liver disease in the community, where previous studies have discovered a large burden of previously unidentified but significant liver disease, is therefore a feasible place to develop new liver disease investigation pathways using the

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adult patients aged 18 years or over (male or female) with primary risk factor for liver disease: * Hazardous alcohol use (\>14 units/week for women, \>21 units/week for men) * Type 2 Diabetes * Obesity * Persistently elevated ALT with normal liver serology Exclusion Criteria: * Active malignancy at study enrolment * Inability to provide informed consent for study enrolment * Known presence of histologically proven liver disease prior to pilot pathway participation
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What it tests

  • Fibrosis Biomarkers
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Where

1 site
NIHR Nottingham Digestive Diseases Biomedical Research Unit
Nottingham, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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