Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality

Inclusion Criteria: * Men and women aged 40-64 at the time of signing the consent form * Willingness to get involved in the study irrespective in which of the study arms (after detailed information on the potential benefits and risks that this study may confer) * The person has signed a consent form (including the acceptance of transporting the samples over the borders, as appropriate) * To be in good health, as determined by a physical examination and history performed by a study physician at enrolment Exclusion Criteria: * Personal history of gastric cancer (prevalent gastric cancer cases will not be revealed at the time of inclusion, and therefore will be included) * Gastric resections due to benign disease (ulcer suturing and vagotomy are accepted) * H. pylori eradication therapy within 12 months prior to inclusion (irrespective of the treatment result) * Presence of alarm symptoms for digestive or any other diseases (detailed in the questionnaire or during the physician evaluation) * Pathological findings at physical investigation suggestive for a serious organic disease (physician evaluation) * Serious co-morbid condition with life expectancy less than 5 years (physician evaluation) * Factors otherwise limiting the participation according to the protocol conditions (problems of mobility, etc.) * Serious psychological conditions/psychiatric disease limiting the possibilities to understand the requirements for diagnostic and/or medical interventions (physician evaluation) * Low expectations on the compliance for the diagnostic work-up or treatment (physician evaluation) * Expected loss for the follow-up (e.g. lack of communication possibilities and data entry in the registries, expected travel abroad, etc.) (physician evaluation) * Signed consent form is not available