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Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

RecruitingNAAges 16 Years - anyAllImperial College London
NCT02222844 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Have a suspected or proven sigmoid colon adenocarcinoma 2. Is eligible for curative treatment 3. Has no irresectable metastatic disease 4. MRI can be reviewed by an MDT prior to surgery 5. Has no decision regarding radical treatment 6. Have provided written informed consent to participate in the study 7. Be aged 16 years or over Exclusion Criteria: 1. Have metastatic disease (including resectable liver metastases) 2. Have a synchronous second malignancy 3. Are contraindicated for MRI 4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30) 5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy
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What it tests

  • Preoperative MRI scan
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Where

16 sites
Hinchingbrooke Hospital
Huntingdon, United Kingdom
Leighton Hospital
Crewe, United Kingdom
University Hospital of North Tees
Stockton-on-Tees, United Kingdom
Croydon University Hospital
Thornton Heath, United Kingdom
Chesterfield Royal
Chesterfield, United Kingdom
Queen Alexandra Hospital
Portsmouth, United Kingdom
St Mark's Hospital
Middlesex, United Kingdom
Maidstone Hospital
Maidstone, United Kingdom

…and 8 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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