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DOvEEgene/WISE Genomics: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics

Recruitingn/aAges 18 Years - anyFemaleMcGill University
NCT02288676 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to develop and validate a test for detecting ovarian and endometrial cancers early. It relies on detecting somatic mutations that are associated with these cancers from a uterine pap test. A saliva sample is also collected that acts as an internal control and has the ability to detect deleterious germline mutations associated with common hereditary cancers (such as breast, ovarian, endometrial, colon, and pancreatic cancers). A machine learning classifier is then used to discriminate between cancer and benign disease.

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📋 Eligibility rules (as published)
Case Inclusion: * Subjects should have suspected or confirmed cancer of the upper genital tract. * Participant will undergo surgery for tumour removal. Control inclusion: • Subjects should be scheduled to have a hysterectomy, bilateral salpingectomy, with or without bilateral oophorectomy, for presumed benign disease.
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What it tests

  • Not listed
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Where

1 site
Royal Victoria Hospital (Glen Site)
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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