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โ† Trials
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Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Recruitingn/aAges 10 Years - 13 YearsFemaleUniversity of Colorado, Denver
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic c

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Females aged 10-13 years * Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees) Exclusion Criteria: * Patients with scoliosis other than idiopathic * Trauma * Inflammatory disease * Malignancies * Diabetes * History of previous spine surgery
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What it tests

  • Not listed
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Where

1 site
Children'S Hospital of Colorado
Denver, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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