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Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

RecruitingNAAges 18 Years - 75 YearsAllSpaulding Rehabilitation Hospital
NCT02323945 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 and 75 years (the latter to reduce likelihood of heart disease) * Medical clearance to participate * Lesion at or below C2 and above T12 with non-progressive etiology * Classified as motor-incomplete with visible volitional leg movement * Injury greater than 1 year Exclusion Criteria: * Concurrent severe medical illness (i.e., infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed decubiti, and history of pulmonary complications) * Pregnant women because of the unknown affects of AIH on pregnant women and fetus * History of seizures, brain injury, and/or epilepsy * Undergoing concurrent physical therapy * Diabetes * Cirrhosis * Caffeine and/or NSAID allergies or intolerances
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What it tests

  • AIH
  • Walk
  • Strength
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Where

1 site
Spaulding Rehabilitation Hospital
Cambridge, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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