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The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection

RecruitingNAAges 18 Years - 85 YearsAllSeoul National University Bundang Hospital
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In plain words

What the trial is, and whether it could suit you

To compare the eradication success rate between 10-days sequential therapy and 7-days tailored therapy based on H. pylori culture and antimicrobial susceptibility testing.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * The patients who proved H. pylori infection following three methods 1. positive rapid urease test (CLOtest) 2. histologic evidence of H. pylori by modified Giemsa staining 3. positive Urea breath test * Male and female Korean Adult (Aged โ‰ฅ 18 years) Exclusion Criteria: * Patients who received eradication therapy for H. pylori infection, previously * H. pylori eradication failure because of poor compliance * the administration of antibiotics or the consumption of bismuth salts within 4 weeks or the administration of a proton pump inhibitor (PPI) within 2 weeks * Advanced gastric cancer or other malignancy * Abnormal liver function or liver cirrhosis * Abnormal renal function or chronic kidney disease * Other severe concurrent diseases * Previous allergic reactions to the study drugs * Pregnant or lactating women
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What it tests

  • 10 day sequential therapy (Esomeprazole, amoxicillin, clarithromycin, metronidazole)
  • 7 day tailored PPI triple therapy (clarithromycin-containing triple therapy)
  • 7 day moxifloxacin based triple therapy [Esomeprazole, Moxifloxacin, Amoxicillin]
  • 7 or 14 days tailored EBMT therapy group (bismuth quadruple therapy)
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Where

1 site
Seoul National University Bundang Hospital
Seongnam-si, South Korea
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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