Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

* INCLUSION CRITERIA FOR UROTHELIAL CANCER PARTICIPANTS: * Adults (\>= 18 years of age) with biopsy-proven or suspected urothelial cancer who require and are willing to undergo diagnostic or therapeutic intervention as part of their diagnosis, standard of care treatment, or follow-up/surveillance for their neoplasm. * ECOG performance status of 0-3. * Must be willing and able to provide informed consent. EXCLUSION CRITERIA: * Subjects who are pregnant. * Subjects co-morbidities preclude diagnostic or therapeutic intervention. Co-morbidities include: --Ongoing treatment for another non-skin malignancy. * History of hepatitis B/C or HIV. Patients who are HIV positive are excluded from this study because treatment with immunomodulatory agents for immunosuppressed patients would affect sample analysis and skew the data. ELIGIBILITY CRITERIA FOR HEALTHY VOLUNTEERS INCLUSION CRITERIA: -Adults (greater than or equal to 18 years of age) and able to give informed consent. EXCLUSION CRITERIA: * Subjects who are pregnant. * Diagnosis of cancer requiring treatment other than minor resection of basal cell or squamous cell skin cancers. * Heart, lung, kidney disease, or other medical conditions as per Principal Investigator discretion. * History of acute or chronic hepatitis B/C or HIV infection. Patients who are HIV positive are excluded from this study because treatment with immunomodulatory agents for immunosuppressed patients would affect sample analysis and skew the data. * Healthy volunteers who are family members with germline mutations.