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Sympatholysis in Chronic Kidney Disease

RecruitingPhase 1Ages 18 Years - 75 YearsAllEmory University
NCT02411773 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Veterans with Stages III and IV Chronic Kidney Disease (CKD) * Kidney transplant recipients with varying degrees of kidney function * Veterans 18-75 years old, without kidney disease, as study controls * Exercise less than 20 minutes twice per week * Willing and able to cooperate with the protocol Exclusion Criteria: * Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute) * Metabolic alkalosis (serum bicarbonate \> 28 meq/L) * Ongoing drug or alcohol abuse * Diabetic neuropathy * Any serious systemic disease that might influence survival * Severe anemia with hemoglobin (Hbg) level \< 10 g/dL * Clinical evidence of congestive heart failure or ejection fraction below 35% * Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history * Treatment with central alpha agonists (clonidine) * Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg * Low blood pressure with BP less than 100/50 mmHg * Pregnancy or plans to become pregnant * Current treatment with monoamine oxidase inhibitors (MAOIs) * Inability to exercise on a stationary bicycle
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What it tests

  • Sodium Bicarbonate
  • Placebo
  • Exercise Training
  • Control to Exercise (Stretching)
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Where

1 site
Atlanta VA Medical Center
Decatur, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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