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Genome Transplant Dynamics

Recruitingn/aAges 14 Years - 80 YearsAllNational Heart, Lung, and Blood Institute (NHLBI)
NCT02423070 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study Description: Heart and lung transplants can save lives, but long-term success is often limited by organ rejection that is hard to detect early. This study is testing a new, non-invasive blood test that looks for small pieces of DNA from the donor organ in the patient s blood. We believe higher levels of this donor DNA may signal early rejection before damage becomes permanent. Hypothesis: We believe that measuring donor-derived DNA in the blood can help detect early signs of rejection and improve outcomes for transplant patients. The study also collects genetic and biological samples to explore why some people are more at risk of complications after transplant. This may help guide future research and treatments. Who Can Join the Study: People receiving a heart or lung transplant (or both), age 14 and older People who are within three months of their transplant People who ca

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: * Lung and heart transplant candidates. Dual organ transplants such as those that include lung or heart PLUS any other organ are also considered for enrollment. * Subjects who have undergone lung or heart transplants and are within 3 months of transplantation. * 14 years and older * Able to understand and be willing to sign the informed consent form. Subjects undergoing a double transplant will sign a single consent. * Retransplant candidates will be considered as a new transplants. These subjects will be approached for enrollment and if they consent to participate, they will be assigned a different SSPIN. EXCLUSION CRITERIA: -Pregnancy
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What it tests

  • Not listed
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Where

7 sites
Dignity Health St. Joseph's Hospital and Medical Center Norton Thoracic Institut
Phoenix, United States
MedStar Washington Hospital Center
Washington D.C., United States
Johns Hopkins University
Baltimore, United States
University of Maryland
Baltimore, United States
National Institutes of Health Clinical Center
Bethesda, United States
INOVA Fairfax Medical
Falls Church, United States
Virginia Commonwealth University
Richmond, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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