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Antibiotic Dosing in Pediatric Intensive Care

Recruitingn/aAges 1 Day - 16 YearsAllUniversity Hospital, Ghent
NCT02456974 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients admitted to the pediatric intensive care unit * patient age/weight : 1,8 kg-15 years * patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines * intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred) Exclusion Criteria: * no catheter in place for blood sampling * absence of parental/patient consent * known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides * extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )
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What it tests

  • blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care
  • blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care.
  • blood sampling in patients receiving vancomycin as part of routine clinical care.
  • blood sampling in patients receiving teicoplanin as part of routine clinical care.
  • blood sampling in patients receiving meropenem as part of routine clinical care.
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Where

1 site
Ghent University Hospital, Hospital Pharmacy
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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