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Pediatric Arm of DZL All Age Asthma Cohort

Recruitingn/aAges 6 Months - 18 YearsAllLMU Klinikum
NCT02496468 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).

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📋 Eligibility rules (as published)
Inclusion Criteria: * informed consent by parents (and by children if age \> 8 years) * age 6 months to 18 years * term delivery (≥ 37 weeks) * active/passive understanding of German * age 6 months - \< 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion) * age at least 6 years: doctor diagnosed asthma (according to current guidelines) Exclusion Criteria: * known inborn or perinatal pulmonary disease * airway malformation * oxygen therapy after birth with a duration of more than 24 hours * ventilator support or mechanical ventilation after birth * diagnoses of cystic fibrosis; primary ciliary dyskinesia * heart failure diagnosed after birth affecting pulmonary circulation * major respiratory diseases such as e.g. interstitial lung disease * any current non-atopic comorbidity * fever of at least 38.5°C during the last two weeks prior to the planned first visit
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What it tests

  • Not listed
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Where

5 sites
University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology
Cologne, Germany
Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease
Hanover, Germany
Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North
Lübeck, Germany
Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center
Marburg, Germany
Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich
Munich, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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