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โ† Trials
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Third Party Viral Specific T-cells (VSTs)

RecruitingPhase 2Ages 2 Days - anyAllChildren's Hospital Medical Center, Cincinnati
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Immunocompromised patient with evidence of viral infection or reactivation * Age \>1 day * Recipients who have had a stem cell transplant must be at least 21 days after stem cell infusion * Clinical status must allow tapering of steroids to \< 0.5mg/kg prednisone or other steroid equivalent * Must be able to receive CTL infusion in Cincinnati * Informed consent obtained by PI or sub-investigator either in person or by phone Exclusion Criteria: * Active acute GVHD grades II-IV * Uncontrolled bacterial or fungal infection * Uncontrolled relapse of malignancy requiring treatment with chemotherapy * Infusion of ATG or alemtuzumab within 2 weeks of VST infusion * Biopsy confirmed acute rejection of solid organ transplant OR empiric treatment of suspected but not confirmed acute rejection of solid organ transplant within the last 30 days
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What it tests

  • Viral Specific VST Infusion
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Where

4 sites
Akron Children's Hospital
Akron, United States
University of Cincinnati Medical Center
Cincinnati, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
The Ohio State University Wexner Medical Center - James Cancer Hospital
Columbus, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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