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Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

RecruitingPhase 2Ages 18 Years - 65 YearsAllEmory University
NCT02560805 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will also test if a medicine called losartan improves high adrenaline levels in patients with PTSD and if a certain gene that has to do with high blood pressure might be associated with high adrenaline levels.

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📋 Eligibility rules (as published)
Inclusion Criteria: * veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race. Exclusion Criteria: * pregnancy * hypertension * diabetes * heart or vascular disease * illicit drug use * excessive alcohol use (\>2 drinks per day) * hyperlipidemia * autonomic dysfunction * current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE) inhibitors, or angiotensin II receptor blockers (ARBs) * treatment with monoamine oxidase (MAO) inhibitors within the last 14 days * any serious systemic disease * chronic kidney disease defined as estimated glomerular filtration rate (GFR) \< 60 cc/min * hyperkalemia (serum potassium \> 5 meq/dL) * systolic blood pressure \< 100 mm Hg * diastolic blood pressure \< 60 mm Hg * heart rate \< 50 beats/min * known hypersensitivity to ARBs or beta blockers
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What it tests

  • Microneurography
  • Combat virtual reality video clip
  • Handgrip Exercise
  • Cold Pressor Test (CPT)
  • Sodium Nitroprusside (SNP)
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Where

1 site
Atlanta VA Medical Center
Decatur, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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