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Response of the Myocardium to Hypertrophic Conditions in the Adult Population

Recruitingn/aAges 21 Years - 99 YearsAllNational Heart Centre Singapore
NCT02670031 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function. Ultimately, heart failure occurs as a result of progressive muscle cell death and scarring (myocardial fibrosis). Dedicated techniques using cardiovascular magnetic resonance imaging (MRI) and novel high-sensitivity cardiac troponin blood assays are potential markers to detect myocardial fibrosis. Although hypertension-related heart disease is very common in Singapore, the significance of myocardial fibrosis is not well understood. In this study, the significance of myocardial fibrosis in 2000 patients with hypertension would be investigated. This will be the largest study using state-of-the-art MRI to examine the importance of myocardial fibrosis in hypertensive he

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. 21 years and over 2. Physician diagnosed essential hypertension, on at least 1 medication for blood pressure control 3. Newly diagnosed hypertension: systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) on at least 2 office visits (Weber 2013) and not started on any anti hypertensive medications at time of ambulatory blood pressure monitoring 4. Resistant hypertension: persistent systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) despite on at least 3 anti-hypertensive medications (Jennings 2013; Weber 2013) Exclusion Criteria: 1. Known secondary hypertension: renal causes (renal artery stenosis, chronic renal failure); endocrine causes (aldosterone excess, pheochromocytoma, cushing's syndrome, hyperthyroidism); cardiac causes (coarctation of the aorta) 2. Contraindications to cardiovascular magnetic resonance: implantable devices, cerebral aneurysm clips, cochlear implants, renal impairment (GRF \<30ml/min/1.73m2), claustrophobia and women who are pregnant or breast-feeding 3. Limited life expectancy 4. On-going unstable medical conditions: hypertensive crisis, acute coronary syndromes or acute heart failure 5. History of coronary artery disease, ischemic heart disease 6. History of transient ischemic attacks or cerebrovascular events 7. History of atrial fibrillation 8. History of heart failure
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What it tests

  • Cardiovascular Magnetic Resonance
  • Echocardiogram
  • Electrocardiogram
  • Ambulatory Blood Pressure Monitoring
  • Retinal Photography (Optional)
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Where

1 site
National Heart Centre Singapore
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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