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Vitamin D Dynamics in Women

Recruitingn/aAges 20 Years - 39 YearsFemaleCornell University
NCT02705287 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this project is to utilize stable isotopically labeled vitamin D3 and state of the art mass spectrometric methodology to assess vitamin D dynamics during pregnancy in relation to relation to obesity and vitamin D binding protein genotype. At the conclusion of this study, the investigators will have obtained novel information on the absorption and utilization of vitamin D in women and the degree to which vitamin D utilization during pregnancy is impacted by genetic ancestry, vitamin D binding protein concentration and genotype and by excess adiposity. The long-term goal is to better understand the unique metabolism of vitamin D during pregnancy.

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📋 Eligibility rules (as published)
Inclusion Criteria (Non-pregnant and pregnant participants participants): * Self-reported White and Black women * Age 20-39 * Body mass index (BMI) 1or pre-pregnancy BMI (If currently pregnant) either 18.5-24.9 kg/m2 or greater than or equal to 30 kg/m2 Inclusion Criteria (Additional criteria for pregnant participants): * Singleton pregnancy * Recruited in first trimester, second trimester, or third trimester * No pregnancy complications Exclusion Criteria (Non-pregnant and pregnant participants): * BMI or pre-pregnancy BMI \<18.5 kg/m2 * Human immunodeficiency virus (HIV) infection * Diagnosed eating disorder * Malabsorption disease * Diabetes * Elevated diastolic blood pressure (\>110 mm/Hg) * Steroid use * Substance abuse history * Current use of medications known to influence vitamin D or calcium homeostasis * Plans to travel to lower latitude during the 20-day study period * Plans to become pregnant during the study period (non-pregnant only) * Refuses to discontinue tanning bed use during study period * Refuses to discontinue vitamin or mineral supplement use during study period (non-pregnant only) Exclusion Criteria (Additional criteria for pregnant participants): * Gestational diabetes * Pregnancy hypertension
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What it tests

  • Vitamin D dynamics-pregnant
  • Vitamin D dynamics-nonpregnant
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Where

1 site
University of Rochester, 518 Hylan Building
Rochester, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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