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Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

RecruitingNAAges 18 Years - anyAllHospices Civils de Lyon
NCT02748941 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebrovascular accident (CVA) constitutes a major health public problem. This represents the second cardiovascular death cause. CVA is ischemic in 80% of cases. Atheroma of large arteries, mainly carotid, is involved in about 20% of cases. After several high grade studies (NASCET, ECST, ACAS, ACST), carotid surgery is based on stenosis calculation by Doppler ultrasound, CT angiography, MRI angiography or arteriography. The composition of the plaque, showing its vulnerability, is associated with embolic risk and stroke. The therapeutic strategy based only on the narrowing of the arterial lumen is not satisfactory enough to prevent the occurrence of a transient ischemic attack (TIA) or an ipsilateral stroke due to carotid stenosis. Thus, new techniques emerge, to evaluate in vivo the inflammation of the plaque, its embolic consequences or the mechanical stress it undergoes. These techni

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📋 Eligibility rules (as published)
Inclusion Criteria: * Carotid stenosis ≥ 50% NASCET * Case: ipsilateral carotid stenosis stroke, certified by MRI or CT in the preceding month, with no others causes of stroke * Control: no clinical sign or MRI hint for a recent stroke * Signed informed consent form * Patient affiliated to a social security system or equivalent Exclusion Criteria: * Modified Rankin scale \> 3 * Homolateral stroke or TIA \> 1 month * Medical history of homolateral carotid surgery, cervical radiation, carotid occlusive, homolateral intracranial stenosis, risk of developing arterial thromboembolic events * Renal failure (creatinine clearance \< 50 ml/min) * Contraindication to ultrasound (sonovue) * Contraindication to MRI and its contrast media (Gadolinium) * Inability to sign informed consent * Inability to undergo any of the technics (claustrophobia…) * Serious co-morbid disease, dementia * Neurological disease with no carotid disease * Risk of pregnancy or pregnancy or breastfeeding * Adult under reinforced guardianship or legal guardian * Patient not understanding French
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What it tests

  • HITS quantification, Ultrasound examinations, High Resolution MRI
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Where

1 site
Hospices Civils de Lyon - Service de radiologie
Bron, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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