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Personalized Indications for CBT and Antidepressants in Treating Depression

RecruitingPhase 4Ages 18 Years - anyAllNova Scotia Health Authority
NCT02752542 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Depression currently affects close to 2 million Canadians and is the leading cause of disability worldwide. Pharmacological treatments (antidepressant medication) and psychological treatments such as cognitive-behavioural therapy are available for depression, but the majority of those who receive treatment have an unsatisfactory response. On average, the combination of pharmacological and psychological treatment achieves better results than either treatment alone. However, the apparently superior results of combination treatment may be due to the fact that different individuals preferentially respond to pharmacological or psychological treatment. The invesitagtors have discovered several clinical factors and biomarkers that predict poor response to commonly used antidepressant medication: history of childhood maltreatment, loss of interest and reduced activity, a biomarker of systemic in

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📋 Eligibility rules (as published)
Inclusion Criteria: * a diagnosis of MDD or PDD established with the Structured Clinical Interview for DSM-5 (SCID-5), and depression being the primary problem requiring clinical attention (judgement of intake clinician). * a minimum current severity of 14 on the 17-item Hamilton Rating Scale for Depression (HRSD-17) * a cumulative duration of depression of at least two months (this will exclude short-lasting first depressive episodes that do not require treatment of this intensity), age 18 or more (no upper limit) * capacity to provide informed consent. Exclusion Criteria * lifetime diagnosis of bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective disorder, or current alcohol or drug use disorder * pregnancy * recent receipt of adequate trial of psychological treatment (10 or more sessions in the past 12 months) * recently introduced antidepressant medication (new antidepressant in past 12 weeks or dose increase in the past 6 weeks) * previous non-response to two or more of study medications * acute suicide risk (MADRS suicide item≥4) * current psychotic symptoms.
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What it tests

  • Cognitive Behavioral Therapy
  • Pharmacotherapy
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Where

1 site
Nova Scotia Health Authority
Halifax, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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