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Clinical and Molecular Studies in Families With Inherited Eye Disease

Recruitingn/aAges 4 Years - 120 YearsAllNational Eye Institute (NEI)
NCT02771236 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Genes are the basic units of heredity. When genes are changed, certain cells don t work like they should. Researchers want to try to better understand the genetic conditions that are linked with inherited eye diseases. Objective: To try to identify the genes linked to the development of inherited eye diseases. Eligibility: People ages 4 and older who have or have a family member with an inherited eye disease Design: Participants will be screened with medical history and medical records. Participants will have one visit that will take 3-4 hours. This will include: Medical and family history Eye exam: This includes the pupil being dilated. Electroretinography: A small electrode is taped to the forehead. Participants sit in the dark with their eyes patched for 30 minutes. Then numbing drops and contact lenses are put in the eyes. They will watch flashing lights. Bl

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: To be eligible, the following inclusion criteria must be met, where applicable; 1. Participant must be four years of age or older. 2. Participant must understand and sign the protocol s informed consent document. 3. Individuals or family members of individuals with inherited eye diseases, either congenital, childhood, or age related. 4. All participants must be able to cooperate with study examination and phlebotomy. EXCLUSION CRITERIA: A participant is not eligible if any of the following exclusion criteria are present: 1. Participant has a disease, infection, or trauma that mimics inherited cataracts, retinal degenerations, glaucoma, etc. 2. Participant has a significant active infection (an infection requiring treatment as determined by the investigator) or a history of chronic or recurrent infections. 3. Participant requires sedation for study purposes.
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What it tests

  • Not listed
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Where

10 sites
University of California, San Diego
La Jolla, United States
National Institutes of Health Clinical Center
Bethesda, United States
Duke University Eye Center
Durham, United States
Eye Research Institute, Zhongshan Ophthalmic Center, Sun Yat Sen University
Guangzhou, China
Aravind Medical Research Foundation
Madurai, India
Seconda Universita di Napoli
Naples, Italy
National Centre of Excellence in Molecular Biology, University of the Punjab
Lahore, Pakistan
University of the Philippines
Manila, Philippines

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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